Q59WH0 · ADA2_CANAL
- ProteinTranscriptional adapter 2
- GeneADA2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids445 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B. Required for expression of many CAS5-dependent genes. Plays a key role in cell wall integrity, cell adhesion, hyphal development and pathogenesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 13 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 25 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 28 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 34 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 37 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 47 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 51 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscriptional adapter 2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ59WH0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000422794 | 1-445 | Transcriptional adapter 2 | ||
Structure
Family & Domains
Features
Showing features for zinc finger, domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Zinc finger | 5-61 | ZZ-type | |||
Domain | 63-115 | SANT | |||
Region | 319-360 | Disordered | |||
Compositional bias | 322-360 | Polar residues | |||
Domain | 357-445 | SWIRM | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length445
- Mass (Da)51,110
- Last updated2017-03-15 v2
- Checksum906898F5F06FF2F2
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 322-360 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017623 EMBL· GenBank· DDBJ | AOW26713.1 EMBL· GenBank· DDBJ | Genomic DNA |