Q59SF7 · PIR1_CANAL

Function

function

Component of the outer cell wall layer required for stability of the cell wall and specifically for cell wall rigidity.

Features

Showing features for site.

138550100150200250300350
TypeIDPosition(s)Description
Site88Covalent attachment to cell wall glycan
Site107Covalent attachment to cell wall glycan
Site125Covalent attachment to cell wall glycan
Site146Covalent attachment to cell wall glycan
Site163Covalent attachment to cell wall glycan
Site183Covalent attachment to cell wall glycan
Site200Covalent attachment to cell wall glycan
Site220Covalent attachment to cell wall glycan
Site243Covalent attachment to cell wall glycan

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentfungal biofilm matrix
Cellular Componentfungal-type cell wall
Cellular Componentyeast-form cell wall
Molecular Functionstructural constituent of cell wall
Biological Processcellular response to temperature stimulus
Biological Processfungal-type cell wall organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell wall mannoprotein PIR1
  • Alternative names
    • Protein with internal repeats 1

Gene names

    • Name
      PIR1
    • Synonyms
      PIR2
    • ORF names
      CaO19.220, CaO19.7851
    • Ordered locus names
      CAALFM_C208870CA

Organism names

Accessions

  • Primary accession
    Q59SF7
  • Secondary accessions
    • A0A1D8PIA7
    • Q59SC4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Increases sensitivity to calcofluor white and Congo red.

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000042862919-385Cell wall mannoprotein PIR1
Glycosylation272N-linked (GlcNAc...) asparagine

Post-translational modification

Covalently linked to beta-1,3-glucan of the inner cell wall layer via an alkali-sensitive ester linkage between the gamma-carboxyl group of glutamic acids, arising from specific glutamines within the PIR1/2/3 repeats, and hydroxyl groups of glucoses of beta-1,3-glucan chains.
Highly O-glycosylated by PMT1 and contains one N-mannosylated chain.

Keywords

PTM databases

Expression

Induction

Expression varies during the cell-cycle with a peak at the beginning of G1. Expression increases in hypoxic and acidic conditions and is down-regulated during the switch from yeast to hyphal growth and under low-iron conditions. The promoter contains E-box consensus sequences (CANNTG) suggesting that PIR1 is directly regulated by EFG1. Expression is also regulated by ACE2, HOG1, and RIM101.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat, region.

TypeIDPosition(s)Description
Repeat78-96PIR1/2/3 1
Repeat97-115PIR1/2/3 2
Repeat116-133PIR1/2/3 3
Repeat136-153PIR1/2/3 4
Repeat154-171PIR1/2/3 5
Repeat173-190PIR1/2/3 6
Repeat191-208PIR1/2/3 7
Repeat210-228PIR1/2/3 8
Repeat233-251PIR1/2/3 9
Region257-282Disordered

Domain

The PIR1/2/3 repeats are required for covalent linkage to the cell wall.

Sequence similarities

Belongs to the PIR protein family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    385
  • Mass (Da)
    40,621
  • Last updated
    2017-03-15 v2
  • Checksum
    2A24722AFC101884
MKYSTLVSIAAFISTSLAATVPDEHYSTLSPSAKIPSGASTDFSGTFGIQVVTVESASALSTDTATSTLTRNDNKKEATPVAQITDGQVQHQTTGGVSAIKQISDGQVQHQTNAAQPIAQISDGQIQHQTTAKATATPVQQINDGQIQHQTTVQPVAQISDGQIQHQTAKATATPVQQIGDGQIQHQTTVQPVAQISDGQIQHQTVKASATPVQQIGDGQIQHQTTAAAATTASAVKQINDGQIQHQTTTAENVAKAQSDGQAIATGSPSSNSTLSDDDDLSSTIPKACSSANNLEMTLHDSVLKDTHERWGAIVANHQFQFDGPIPQAGTIYSAGWSIKDGYLYLGDSNIFYQCLSGDFYNLYDENVAKQCSAVKLSVIEFVNC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017624
EMBL· GenBank· DDBJ
AOW27875.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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