Q59KI0 · UGP1_CANAL
- ProteinUTP--glucose-1-phosphate uridylyltransferase
- GeneUGP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids500 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a central role as a glucosyl donor in cellular metabolic pathways.
Miscellaneous
Present with 17200 molecules/cell in log phase SD medium.
Catalytic activity
- alpha-D-glucose 1-phosphate + H+ + UTP = diphosphate + UDP-alpha-D-glucose
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 109-112 | UTP (UniProtKB | ChEBI) | ||||
Sequence: LNGG | ||||||
Binding site | 111-112 | substrate | ||||
Sequence: GG | ||||||
Binding site | 123 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 123 | UTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 186 | UTP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 215 | UTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 216 | substrate | ||||
Sequence: H | ||||||
Binding site | 244-246 | substrate | ||||
Sequence: NGD | ||||||
Binding site | 246 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 246 | UTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Active site | 388 | |||||
Sequence: K | ||||||
Binding site | 388 | UTP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Cellular Component | yeast-form cell wall | |
Molecular Function | metal ion binding | |
Molecular Function | UTP:glucose-1-phosphate uridylyltransferase activity | |
Biological Process | (1->6)-beta-D-glucan biosynthetic process | |
Biological Process | glycogen biosynthetic process | |
Biological Process | glycogen metabolic process | |
Biological Process | intein-mediated protein splicing | |
Biological Process | protein glycosylation | |
Biological Process | trehalose biosynthetic process | |
Biological Process | UDP-glucose metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUTP--glucose-1-phosphate uridylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Debaryomycetaceae > Candida/Lodderomyces clade > Candida
Accessions
- Primary accessionQ59KI0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to yeast but not hyphal cell surface.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000424335 | 1-500 | UTP--glucose-1-phosphate uridylyltransferase | |||
Sequence: MATTGKRHAKSQSTYAFDNTATNVTASQMRNALNNLADTVENPEQTTRFENEMDNFFTLFRRYLTEKASGSTLDWDKIRSPSSDEVVEYGDLNSANNSANLSKLAVLKLNGGLGTSMGCVGPKSVIEVRDGNNFLDLAVRQIEHLNRKYDADVPLLLMNSFNTDADTEKIIKKYQSHRIRVKTFNQSRFPRIYKDSLLPVPESFDDSLEAWYPPGHGDLFEALVQSGELDALLAQGREILFVSNGDNLGATVDSKILDHMIETGAEYIMELTPKTRADVKGGTLINYQGEVRLLEIAQVPKEHVEEFKSIKKFKYFNTNNLWINLRAIKKLVEANAIEVEIIPNQKTISHGKSDINVLQLETAVGAAIRHFKGAHGVVVPRSRFLPVKTCSDLLLVKSDLFYLEHGALVLDPTRDGFSNPLIKLGSHFKKVSGFQSRIPYIPKILELDHLTITGNVTIGKGVQLKGTVIIVCNDGDKIDIPNGAILENVVVTGNLTILEH |
Expression
Induction
Expression is up-regulated during oropharyngeal candidiasis (OPC) infection and during stationary phase. Repressed by HOG1, BCR1 and hydrogen peroxide.
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 449-500 | Oligomerization | ||||
Sequence: HLTITGNVTIGKGVQLKGTVIIVCNDGDKIDIPNGAILENVVVTGNLTILEH |
Sequence similarities
Belongs to the UDPGP type 1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length500
- Mass (Da)55,552
- Last updated2017-03-15 v2
- Checksum476B07B548695192
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP017630 EMBL· GenBank· DDBJ | AOW31202.1 EMBL· GenBank· DDBJ | Genomic DNA |