Q59H65 · Q59H65_HUMAN
- ProteinAldehyde dehydrogenase family 3 member A2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids461 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- (2E)-hexadecenal + H2O + NAD+ = (E)-hexadec-2-enoate + 2 H+ + NADH
- 2 H+ + hexadecanoate + NADH = H2O + hexadecanal + NAD+
- 2,6,10,14-tetramethylpentadecanal + H2O + NAD+ = 2,6,10,14-tetramethylpentadecanoate + 2 H+ + NADH
- 22-oxodocosanoate + H2O + NAD+ = docosanedioate + 2 H+ + NADH
- H2O + NAD+ + octadecanal = 2 H+ + NADH + octadecanoate
- H2O + NAD+ + octanal = 2 H+ + NADH + octanoate
- H2O + NAD+ + tetradecanal = 2 H+ + NADH + tetradecanoate
- H2O + heptanal + NAD+ = 2 H+ + heptanoate + NADH
- a fatty aldehyde + H2O + NAD+ = a fatty acid + 2 H+ + NADH
- decanal + H2O + NAD+ = decanoate + 2 H+ + NADH
- dodecanoate + 2 H+ + NADH = dodecanal + H2O + NAD+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 183 | |||||
Sequence: E | ||||||
Active site | 217 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | 3-chloroallyl aldehyde dehydrogenase activity | |
Molecular Function | aldehyde dehydrogenase (NAD+) activity | |
Biological Process | cellular aldehyde metabolic process | |
Biological Process | fatty acid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldehyde dehydrogenase family 3 member A2
- EC number
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ59H65
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 440-458 | Helical | ||||
Sequence: LGLLLLTFLGIVAAVLVKA |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-397 | Aldehyde dehydrogenase | ||||
Sequence: LEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSH |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length461
- Mass (Da)51,892
- Last updated2005-04-26 v1
- Checksum6D1F6F27BF4B709C
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Q |