Q59H65 · Q59H65_HUMAN

  • Protein
    Aldehyde dehydrogenase family 3 member A2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Catalytic activity

  • (2E)-hexadecenal + H2O + NAD+ = (E)-hexadec-2-enoate + 2 H+ + NADH
  • (2E,6E)-farnesal + H2O + NAD+ = (2E,6E)-farnesoate + 2 H+ + NADH
    EC:1.2.1.94 (UniProtKB | ENZYME | Rhea)
  • 2 H+ + hexadecanoate + NADH = H2O + hexadecanal + NAD+
  • 2,6,10,14-tetramethylpentadecanal + H2O + NAD+ = 2,6,10,14-tetramethylpentadecanoate + 2 H+ + NADH
  • 22-oxodocosanoate + H2O + NAD+ = docosanedioate + 2 H+ + NADH
  • H2O + NAD+ + octadecanal = 2 H+ + NADH + octadecanoate
  • H2O + NAD+ + octanal = 2 H+ + NADH + octanoate
  • H2O + NAD+ + tetradecanal = 2 H+ + NADH + tetradecanoate
  • H2O + heptanal + NAD+ = 2 H+ + heptanoate + NADH
  • a fatty aldehyde + H2O + NAD+ = a fatty acid + 2 H+ + NADH
  • an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • decanal + H2O + NAD+ = decanoate + 2 H+ + NADH
  • dodecanoate + 2 H+ + NADH = dodecanal + H2O + NAD+

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site183
Active site217

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Function3-chloroallyl aldehyde dehydrogenase activity
Molecular Functionaldehyde dehydrogenase (NAD+) activity
Biological Processcellular aldehyde metabolic process
Biological Processfatty acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aldehyde dehydrogenase family 3 member A2
  • EC number
  • Alternative names
    • Fatty aldehyde dehydrogenase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q59H65

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane440-458Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-397Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    461
  • Mass (Da)
    51,892
  • Last updated
    2005-04-26 v1
  • Checksum
    6D1F6F27BF4B709C
QQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB208894
EMBL· GenBank· DDBJ
BAD92131.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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