Homo sapiens protein coding cDNA.Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.Cited forNUCLEOTIDE SEQUENCETissueBrainCategorySequencesSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to EMBL/GenBank/DDBJ databases (MAR-2005)Cited in4199+
Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology.Korinek M., Candelas Serra M., Abdel Rahman F., Dobrovolski M., Kuchtiak V., Abramova V., Fili K., Tomovic E., Hrcka Krausova B.[...], Smejkalova T.View abstractAnnotationDisease-Associated Variants in GRIN1 GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure Function and Pathophysiology.SourceGeneRif: 2902PubMedEurope PMCPhysiol Res 73:S413-S434 (2024)Mapped to13
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.Xu Y., Song R., Perszyk R.E., Chen W., Kim S., Park K.L., Allen J.P., Nocilla K.A., Zhang J.[...], Traynelis S.F.View abstractAnnotationDe novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.CategoryFunctionSourceGeneRif: 2902PubMedEurope PMCCell. Mol. Life Sci. 81:153-153 (2024)Cited in3Mapped to10
GRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms.Ragnarsson L., Zhang Z., Das S.S., Tran P., Andersson A., des Portes V., Desmettre Altuzarra C., Remerand G., Labalme A.[...], Keramidas A.View abstractAnnotationGRIN1 variants associated with neurodevelopmental disorders reveal channel gating pathomechanisms.CategorySubcellular LocationSourceGeneRif: 2902PubMedEurope PMCEpilepsia 64:3377-3388 (2023)Mapped to5
Pluripotential GluN1 (NMDA NR1): Functional Significance in Cellular Nuclei in Pain/Nociception.McNearney T.A., Westlund K.N.View abstractAnnotationPluripotential GluN1 (NMDA NR1): Functional Significance in Cellular Nuclei in Pain/Nociception.SourceGeneRif: 2902PubMedEurope PMCInt J Mol Sci 24:13196-13196 (2023)Mapped to5
Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling.Bossi S., Pizzamiglio L., Paoletti P.View abstractAnnotationExcitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling.SourceGeneRif: 2902PubMedEurope PMCTrends Neurosci 46:667-681 (2023)Mapped to7
Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.Xie L., McDaniel M.J., Perszyk R.E., Kim S., Cappuccio G., Shapiro K.A., Munoz-Cabello B., Sanchez-Lara P.A., Grand K.[...], Traynelis S.F.View abstractAnnotationFunctional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.SourceGeneRif: 2902PubMedEurope PMCCell Mol Life Sci 80:110-110 (2023)Mapped to13
NMDA receptor modulation and severe acute respiratory syndrome treatment.Costa B.M.View abstractAnnotationNMDA receptor modulation and severe acute respiratory syndrome treatment.CategoryFunctionSourceGeneRif: 2902PubMedEurope PMCF1000Res 10:Chem Inf Sci-1060 (2021)Mapped to5
Autoimmune Encephalitis with Autoantibodies to NMDAR1 following Herpes Encephalitis in Children and Adolescents.Quade A., Rostasy K., Wickstrom R., Aydin O.F., Sartori S., Nosadini M., Knierim E., Kluger G., Korinthenberg R.[...], Hausler M.View abstractAnnotationAutoimmune Encephalitis with Autoantibodies to NMDAR1 following Herpes Encephalitis in Children and Adolescents.CategorySequencesSourceGeneRif: 2902PubMedEurope PMCNeuropediatrics 54:14-19 (2023)Mapped to5
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.Chou T.H., Kang H., Simorowski N., Traynelis S.F., Furukawa H.View abstractAnnotationStructural insights into assembly and function of GluN1-2C GluN1-2A-2C and GluN1-2D NMDARs.CategoriesFunction, StructureSourceGeneRif: 2902PubMedEurope PMCMol. Cell 82:4548-4563.e4 (2022)Cited in2Mapped to21
Anti-<i>N</i>-Methyl-d-Aspartate Receptor Antibody Testing in First- Episode Psychosis: Universal or Targeted Testing.Cohn S.L., Mohan A., Lappin J.M., Curtis J., Scott J.G.View abstractAnnotationAnti-N-Methyl-d-Aspartate Receptor Antibody Testing in First-Episode Psychosis: Universal or Targeted Testing.CategorySequencesSourceGeneRif: 2902PubMedEurope PMCJ Neuropsychiatry Clin Neurosci 35:98-101 (2023)Mapped to5
Overlapping cortical malformations in patients with pathogenic variants in <i>GRIN1</i> and <i>GRIN2B</i>.Brock S., Laquerriere A., Marguet F., Myers S.J., Hongjie Y., Baralle D., Vanderhasselt T., Stouffs K., Keymolen K.[...], Bahi-Buisson N.View abstractAnnotationOverlapping cortical malformations in patients with pathogenic variants in GRIN1 and GRIN2B.CategorySequencesSourceGeneRif: 2902PubMedEurope PMCJ Med Genet 60:183-192 (2023)Mapped to8
Paradigmatic De Novo <i>GRIN1</i> Variants Recapitulate Pathophysiological Mechanisms Underlying GRIN1-Related Disorder Clinical Spectrum.Santos-Gomez A., Miguez-Cabello F., Julia-Palacios N., Garcia-Navas D., Soto-Insuga V., Garcia-Penas J.J., Fuentes P., Ibanez-Mico S., Cuesta L.[...], Altafaj X.View abstractAnnotationParadigmatic De Novo GRIN1 Variants Recapitulate Pathophysiological Mechanisms Underlying GRIN1-Related Disorder Clinical Spectrum.CategoriesFunction, Disease & VariantsSourceGeneRif: 2902PubMedEurope PMCInt J Mol Sci 22:12656-12656 (2021)Mapped to5
Identification of Hub Gene GRIN1 Correlated with Histological Grade and Prognosis of Glioma by Weighted Gene Coexpression Network Analysis.Yang A., Wang X., Hu Y., Shang C., Hong Y.View abstractAnnotationIdentification of Hub Gene GRIN1 Correlated with Histological Grade and Prognosis of Glioma by Weighted Gene Coexpression Network Analysis.CategoriesFunction, ExpressionSourceGeneRif: 2902PubMedEurope PMCBiomed Res Int 2021:4542995-4542995 (2021)Mapped to5
Lipid bilayers regulate allosteric signal of NMDA receptor GluN1 C- terminal domain.Wang B., Zou L., Zhou L.View abstractAnnotationLipid bilayers regulate allosteric signal of NMDA receptor GluN1 C-terminal domain.CategoryFunctionSourceGeneRif: 2902PubMedEurope PMCBiochem Biophys Res Commun 585:15-21 (2021)Mapped to5
N-methyl-d-aspartate (NMDA) receptor genetics: The power of paralog homology and protein dynamics in defining dominant genetic variants.Charron J.G., Hernandez A., Bilinovich S.M., Vogt D.L., Bedinger L.A., Seaver L.H., Williams M., Devries S., Campbell D.B.[...], Prokop J.W.View abstractAnnotationN-methyl-d-aspartate (NMDA) receptor genetics: The power of paralog homology and protein dynamics in defining dominant genetic variants.CategorySequencesSourceGeneRif: 2902PubMedEurope PMCAm J Med Genet A 188:556-568 (2022)Mapped to13
[mRNA level of N-methyl-D-aspartic acid receptor NR1 subunit in patients with major depressive disorder and its relationship with clinical features].Liao J.W., Ma P., Yang H.H., Pan J.Y.View abstractSourceGeneRif: 2902PubMedEurope PMCZhonghua Yi Xue Za Zhi 101:3227-3231 (2021)Mapped to5
The effect of human GRIN1 gene 5' functional region on gene expression regulation in vitro.Liu Y.P., Wu X., Meng J.H., Xing J.X., Xuan J.F., Xia X., Yao J., Wang B.J.View abstractAnnotationThe effect of human GRIN1 gene 5' functional region on gene expression regulation in vitro.CategoriesSequences, ExpressionSourceGeneRif: 2902PubMedEurope PMCGene 808:145973-145973 (2022)Mapped to5
Structural basis of ketamine action on human NMDA receptors.Zhang Y., Ye F., Zhang T., Lv S., Zhou L., Du D., Lin H., Guo F., Luo C., Zhu S.View abstractAnnotationStructural basis of ketamine action on human NMDA receptors.CategoryStructureSourceGeneRif: 2902PubMedEurope PMCNature 596:301-305 (2021)Cited in2Mapped to11
Recurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy.Xu Y., Song R., Chen W., Strong K., Shrey D., Gedela S., Traynelis S.F., Zhang G., Yuan H.View abstractAnnotationRecurrent seizure-related GRIN1 variant: Molecular mechanism and targeted therapy.CategoriesFunction, SequencesSourceGeneRif: 2902PubMedEurope PMCAnn Clin Transl Neurol 8:1480-1494 (2021)Mapped to5
Correlated conformational dynamics of the human GluN1-GluN2A type N- methyl-D-aspartate (NMDA) receptor.Essiz S., Gencel M., Aktolun M., Demir A., Carpenter T.S., Servili B.View abstractAnnotationCorrelated conformational dynamics of the human GluN1-GluN2A type N-methyl-D-aspartate (NMDA) receptor.CategoryStructureSourceGeneRif: 2902PubMedEurope PMCJ Mol Model 27:162-162 (2021)Mapped to10
Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors.Kolcheva M., Kortus S., Krausova B.H., Barackova P., Misiachna A., Danacikova S., Kaniakova M., Hemelikova K., Hotovec M.[...], Horak M.View abstractAnnotationSpecific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors.CategoryFunctionSourceGeneRif: 2902PubMedEurope PMCNeuropharmacology 189:108528-108528 (2021)Mapped to5
D-serine and NMDA Receptor 1 Expression in Patients with Intractable Epilepsy.Zhang X., Hu B., Lu L., Xu D., Sun L., Lin W.View abstractAnnotationD-serine and NMDA Receptor 1 Expression in Patients with Intractable Epilepsy.CategoriesFunction, SequencesSourceGeneRif: 2902PubMedEurope PMCTurk Neurosurg 31:76-82 (2021)Mapped to5
Exploratory investigation on antibodies to GluN1 and cognitive dysfunction in patients with chronic autoimmune psychosis.Abe K., Chiba Y., Katsuse O., Takahashi Y., Suda A., Hattori S., Yoshimi R., Kirino Y., Kunii M.[...], Hishimoto A.View abstractAnnotationExploratory investigation on antibodies to GluN1 and cognitive dysfunction in patients with chronic autoimmune psychosis.CategoriesFunction, Disease & VariantsSourceGeneRif: 2902PubMedEurope PMCNeurosci Lett 743:135588-135588 (2021)Mapped to5
The NMDAR GluN1-1a C-terminus binds to CaM and regulates synaptic function.Zhou L., Duan J.View abstractAnnotationThe NMDAR GluN1-1a C-terminus binds to CaM and regulates synaptic function.CategoriesFunction, InteractionSourceGeneRif: 2902PubMedEurope PMCBiochem Biophys Res Commun 534:323-329 (2021)Mapped to8