Q59GW0 · Q59GW0_HUMAN

  • Protein
    Glutamate receptor
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

Features

Showing features for binding site, site.

166350100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site270L-glutamate (UniProtKB | ChEBI)
Binding site272L-glutamate (UniProtKB | ChEBI)
Binding site277L-glutamate (UniProtKB | ChEBI)
Site418Crucial to convey clamshell closure to channel opening
Binding site442L-glutamate (UniProtKB | ChEBI)
Site448Interaction with the cone snail toxin Con-ikot-ikot
Binding site486L-glutamate (UniProtKB | ChEBI)
Site532Interaction with the cone snail toxin Con-ikot-ikot

GO annotations

AspectTerm
Cellular ComponentNMDA selective glutamate receptor complex
Cellular Componentpostsynaptic membrane
Molecular Functionligand-gated monoatomic ion channel activity
Molecular Functionsignaling receptor activity
Biological Processglutamate receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Glutamate receptor

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q59GW0

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Postsynaptic cell membrane

Keywords

Disease & Variants

Organism-specific databases

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond498↔552

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain187-549Ionotropic glutamate receptor C-terminal
Domain193-261Ionotropic glutamate receptor L-glutamate and glycine-binding

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    663
  • Mass (Da)
    73,976
  • Last updated
    2005-04-26 v1
  • MD5 Checksum
    D18200AB889A5AFFBF6646EB58A57E60
RAPGTCGWSASARSRGTPCATPRTLINGKNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIKFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQVGQATLRGLVPRARPGHGPPPSPKAVALALALVGRTGARSHGQGQW

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB208999
EMBL· GenBank· DDBJ
BAD92236.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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