Q59GW0 · Q59GW0_HUMAN
- ProteinGlutamate receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids663 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 270 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 272 | L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 277 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 418 | Crucial to convey clamshell closure to channel opening | |||
Binding site | 442 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 448 | Interaction with the cone snail toxin Con-ikot-ikot | |||
Binding site | 486 | L-glutamate (UniProtKB | ChEBI) | |||
Site | 532 | Interaction with the cone snail toxin Con-ikot-ikot | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | NMDA selective glutamate receptor complex | |
Cellular Component | postsynaptic membrane | |
Molecular Function | ligand-gated monoatomic ion channel activity | |
Molecular Function | signaling receptor activity | |
Biological Process | glutamate receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGlutamate receptor
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ59GW0
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Keywords
- Cellular component
Disease & Variants
Organism-specific databases
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 498↔552 | ||||
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 187-549 | Ionotropic glutamate receptor C-terminal | |||
Domain | 193-261 | Ionotropic glutamate receptor L-glutamate and glycine-binding | |||
Sequence similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length663
- Mass (Da)73,976
- Last updated2005-04-26 v1
- MD5 ChecksumD18200AB889A5AFFBF6646EB58A57E60
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB208999 EMBL· GenBank· DDBJ | BAD92236.1 EMBL· GenBank· DDBJ | mRNA |