the results of the present study suggest that miR-96-5p which is frequently upregulated in hepatocellular carcinoma (HCC) inhibits apoptosis by targeting CASP9. Therefore miR-96-5p may be a potential therapeutic target for HCC
Study described rare mutations of the apoptosis gene CASP9 identified in neural tube defect cases and demonstrated that the p.Y251C variant impairs the protein's apoptotic function suggesting it is a loss-of-function variation; also showed that the p.R191G variant inhibited apoptosis under folate-deficient condition highlighting the effect of gene-environment interactions in this complex disease.
CASP9 germline mutations may have played a role at least in part to the susceptibility of development of gliomas in a Li-Fraumeni-like family lacking a TP53 germline mutation.
The caspase 9 level was significantly lower and related with oxidant status in patients with polycystic ovary syndrome while the circulating levels of caspases 3 and 7 were statistically similar in both PCOS and control groups.
Inhibition of TRIAP1 in RPMI8226 cells increased the percentage of apoptotic cells accompanied by increased expression of APAF1 and Caspase 9 and Caspase 9 and Caspase 3/7 activity.
Expression of mutant caspase-9 correlated with a downregulation of BAFFR (B-cell-activating factor belonging to the TNF family (BAFF) receptor) in B cells and ICOS (inducible T-cell costimulator) in T cells.
soluble apoptosis markers as sFas-L Caspase-9 Caspase-8 and sCD153 were significantly higher in stage III obesity patients compared obese patients without food allergy
Data indicate a significant association of two single nucleotide polymorphism (SNPs) in aspase9 (CASP9) and two haplotypes of the four SNP combinations with acute myeloid leukemia (AML) susceptibility.
BIRC5-31CC and CASP9+83CT/TT genotypes were associated with an increased risk for renal cell carcinoma development in the female group of our southern European study population.
The rs4645981 T allele and the rs4645981 T allele carrier might increase the risk of cancer but the rs1052576 A allele rs1052576 A carrier rs2308941 T allele and rs2308941 T carrier might be protective.
results suggest that caspase-4 directly activates caspase-9 by the processing of procaspase-9 at Asp-315 in endoplasmic reticulum stress-induced neuronal apoptosis
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