Q59EB0 · Q59EB0_HUMAN
- ProteinVascular endothelial growth factor receptor 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1451 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 936-943 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GRGAFGQV | ||||||
Binding site | 963 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 1123 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 1127 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 1128 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 1141 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | growth factor binding | |
Molecular Function | metal ion binding | |
Molecular Function | vascular endothelial growth factor receptor activity | |
Biological Process | angiogenesis | |
Biological Process | cell migration | |
Biological Process | endothelial cell differentiation | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | positive regulation of cell migration | |
Biological Process | positive regulation of phosphate metabolic process | |
Biological Process | positive regulation of protein modification process | |
Biological Process | regulation of MAPK cascade | |
Biological Process | vascular endothelial growth factor receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVascular endothelial growth factor receptor 2
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ59EB0
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 860-881 | Helical | ||||
Sequence: IIILVGTAVIAMFFWLLLVIIL |
Keywords
- Cellular component
PTM/Processing
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 319-415 | Ig-like | ||||
Sequence: YDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGITRSDQGLYTCAASSGLMTKKNST | ||||||
Domain | 423-509 | Ig-like | ||||
Sequence: PFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVS | ||||||
Domain | 516-643 | Ig-like | ||||
Sequence: PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVT | ||||||
Domain | 646-755 | Ig-like | ||||
Sequence: PEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT | ||||||
Domain | 762-834 | Ig-like | ||||
Sequence: PTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQA | ||||||
Domain | 929-1257 | Protein kinase | ||||
Sequence: LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGN | ||||||
Region | 1369-1413 | Disordered | ||||
Sequence: DRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTV | ||||||
Compositional bias | 1387-1410 | Polar residues | ||||
Sequence: ESVASEGSNQTSGYQSGYHSDDTD |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,451
- Mass (Da)161,603
- Last updated2005-04-26 v1
- Checksum915FE64B51EFA0CB
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: R | ||||||
Compositional bias | 1387-1410 | Polar residues | ||||
Sequence: ESVASEGSNQTSGYQSGYHSDDTD |