Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New Binding Site for the Early B-Cell Factor 1 That Instigates Adipose Tissue CAV1 Protein Overexpression.
The effect of dietary total antioxidant capacity (DTAC) and Caveolin-1 gene variant interaction on cardiovascular risk factors among overweight and obese women: A cross-sectional investigation.
Potential causal association of a prolonged PR interval and clinical recurrence of atrial fibrillation after catheter ablation: a Mendelian randomization analysis.
The serum cav-1 level was lower in the patients with Moyamoya disease (MMD) than in the controls. In vitro analysis showed that cav-1 downregulation suppressed angiogenesis in the endothelial cells and induced apoptosis in the smooth muscle cells. Findings suggest that cav-1 may play a major role in negative arterial remodeling in MMD.
The CAV1 variation rs11773845 was found to be consistently associated with high serum triglycerides and the metabolic syndrome in an admixed Latin American population.
Age factor is significant in women with single nucleotide polymorphisms G32124A and T28608A of the caveolin-1 (CAV-1) gene. The relationship between cases and controls is significant for T29107A G21985A G14713A and C521A polymorphisms among which only C521A shows a significant difference in body mass index between the 2 groups.
No differences were observed for genotype and allele distributions in relation to rs4236601 in the CAV1/CAV2 region. The association of rs2157719 (CDKN2B-AS1) with the primary open angle glaucoma (POAG) phenotype corroborates previously published results reinforcing the importance of this variant in POAG etiology.
Results found decreasing trend of cav-1 (transcripts I and II) in tumoral tissues especially in stages I and II and seem to be associated with the incidence and promotion of breast cancer especially in the initial stages of breast cancer.
Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy.
This study determined the genetic polymorphisms of the eNOS (Glu298Asp) and Cav-1 (G14713A and T29107A) genes in association with susceptibility risk in patients who had suffered from a large artery atherosclerotic stroke. It demonstrated that the eNOS Glu298Asp in combination with 14713A/29107A at the CAV1 locus was associated with a significant risk of an large artery atherosclerotic stroke.
Sequencing of BMPR2 CAV1 and KCNK3 coding regions did not identify any pathogenic variants in these genes in infants with pulmonary hypoplasia and pulmonary hypertension.
gestational diabetes-induced macrosomias have more severe inhibition of Cav-1 expression in placenta. Cav-1 is associated with placental glucose and fatty acid transport via the induction of AMPK signaling pathway and the reduction of GLUT1 signaling pathway to reverse gestational diabetes-induced macrosomia.
The CpG island shore methylation of CAV1 may play an important role in progression of gastric cardia adenocarcinoma (GCA) and may serve as a prognostic methylation biomarker for GCA patients.
Caveolin-1 is a sensitive Malignant mesothelioma marker and is expressed in a high proportion of cases but lacks association with histology and survival
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