the findings of this study suggest that the downregulation of Cav1 in fibroblasts is associated with an increased tumor proliferation rate in vivo and chemoresistance. Further studies are warranted to explore whether the targeting of Cav1 in the stroma may represent a novel therapeutic approach in pancreatic cancer.
stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 in the metastatic lymph nodes could be associated with lung cancer pathogenesis.
This is the first demonstration of caveolin-1 expression in human primary uveal melanoma cell lines and observation that the origin of cells (uveal/cutaneous) has an impact when considering the utility of caveolin-I as a melanoma cell marker.
using proteomics profiling we identified a new protein caveolin-1 that is significantly and consistently augmented in CLL cells after these lymphocytes interact with stromal cell lines.
Cavin-1 and cavin-2 are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1.
This study demonstrates that caveolin-1 is strongly expressed within caveolae-like structures and associated vesicles within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver.
In prostate cancer cells in culture delta-catenin was co-localized with caveolin-1 and CD59 suggesting its potential excretion into extracellular milieu through exosome/prostasome associated pathways.
caveolin-1(CAV1) was observed in most cells in myomas and in only few cells in controls; CAV1 was localized with oxytocin receptor and sex hormone binding globulin in myomas
Results indicated that caveolin-1 expression may have potential both as a diagnostic marker in the differential diagnosis of renal tumors and as a therapeutic target especially for clear-cell renal cell carcinoma.
increased expression of caveolins in proliferating bile ductules in primary biliary cirrhosis may be related to the homeostasis of cholesterol transport in regenerating bile ductules in liver
In the cerebral cortex caveolin-1 is expressed by all the cell types that form the vascular wall endothelial cells pericytes and vascular astrocytes in vivo.
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