Q59738 · BFR_RHOCA
- ProteinBacterioferritin
- Genebfr
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids161 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Iron-storage protein, whose ferroxidase center binds Fe2+, oxidizes it using dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the BFR protein shell.
Catalytic activity
- 4 Fe2+ + O2 + 4 H+ = 4 Fe3+ + 2 H2O
- Fe2+(in) = Fe2+(out)
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 18 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 51 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 51 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 52 | Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); ligand shared between dimeric partners; axial binding residue | |||
Binding site | 54 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 94 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 127 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 127 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 130 | Fe cation 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ferric iron binding | |
Molecular Function | ferrous iron transmembrane transporter activity | |
Molecular Function | ferroxidase activity | |
Molecular Function | heme binding | |
Biological Process | intracellular sequestering of iron ion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBacterioferritin
- EC number
- Short namesBFR
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Rhodobacter
Accessions
- Primary accessionQ59738
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000192611 | 1-161 | Bacterioferritin | ||
Interaction
Subunit
Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.
Structure
Sequence
- Sequence statusComplete
- Length161
- Mass (Da)18,173
- Last updated1997-11-01 v1
- Checksum9E534CBC531EC709
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z54247 EMBL· GenBank· DDBJ | CAA91017.1 EMBL· GenBank· DDBJ | Genomic DNA |