Q59121 · PLD_ARCHD

Function

function

Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site46

GO annotations

AspectTerm
Molecular Functionsphingomyelin phosphodiesterase D activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase D
  • EC number
  • Short names
    PLD
    ; PLD-A
  • Alternative names
    • Choline phosphatase
    • Sphingomyelinase D
      (SMaseD
      ) (EC:3.1.4.41
      ) . EC:3.1.4.41 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      pld
    • Ordered locus names
      Arch_1099

Organism names

Accessions

  • Primary accession
    Q59121
  • Secondary accessions
    • D7BPG4

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000002206527-309Phospholipase D

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    309
  • Mass (Da)
    34,663
  • Last updated
    1997-11-01 v2
  • Checksum
    C34AC5B947A21725
MKTRKKIALALSLLTGFMLPIGSAAAAPLAQEQPTTGNRPVYAIAHRVLTKQSVDDAIKIGANALEIDFTAWRRGWWADHDGLPTSAGDTAEDILKYIAQKRREGNNITFVWFDIKNPDYCKDQNSVCSITKLRDLARQTIEQEGVRALFGFYKTVGGVGWNTIANNLNDKEAVALSGRKDDIMKDFKQYENKIKPQQRVADNGYYNLSYGFGGCYRDENQTCDQLRLAGEERKKGNLGKTFGWTVSTGQEYLAADLLNKAEVDGMIFGFKTTYFYDHADTRNAFAGIKNWVDAHQGTHHMATNKDIPW

Sequence caution

The sequence AAA21882.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.
The sequence ADH92813.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L16583
EMBL· GenBank· DDBJ
AAA21882.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation
CP002045
EMBL· GenBank· DDBJ
ADH92813.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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