Q59121 · PLD_ARCHD
- ProteinPhospholipase D
- Genepld
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids309 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Virulence factor affecting bacterial dissemination and survival within the host. Has magnesium-dependent catalytic activity toward sphingomyelin (SM) and acyl- and alkyl-lysophosphatidylcholine (LPC), but not toward sphingosylphosphorylcholine (SPC) and phosphatidylcholine (PC). Lysophosphatidic acid (LPA), assumed to result from LPC hydrolysis, evokes pathophysiological responses after LPA receptor internalization. Shows hemolytic activity.
Catalytic activity
- a sphingomyelin + H2O = an N-acylsphing-4-enine 1-phosphate + choline + H+
- 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + choline + H+
- 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H+
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 46 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | sphingomyelin phosphodiesterase D activity | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhospholipase D
- EC number
- Short namesPLD ; PLD-A
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Actinomycetales > Actinomycetaceae > Arcanobacterium
Accessions
- Primary accessionQ59121
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MKTRKKIALALSLLTGFMLPIGSAAA | ||||||
Chain | PRO_0000022065 | 27-309 | Phospholipase D | |||
Sequence: APLAQEQPTTGNRPVYAIAHRVLTKQSVDDAIKIGANALEIDFTAWRRGWWADHDGLPTSAGDTAEDILKYIAQKRREGNNITFVWFDIKNPDYCKDQNSVCSITKLRDLARQTIEQEGVRALFGFYKTVGGVGWNTIANNLNDKEAVALSGRKDDIMKDFKQYENKIKPQQRVADNGYYNLSYGFGGCYRDENQTCDQLRLAGEERKKGNLGKTFGWTVSTGQEYLAADLLNKAEVDGMIFGFKTTYFYDHADTRNAFAGIKNWVDAHQGTHHMATNKDIPW |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length309
- Mass (Da)34,663
- Last updated1997-11-01 v2
- ChecksumC34AC5B947A21725
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L16583 EMBL· GenBank· DDBJ | AAA21882.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
CP002045 EMBL· GenBank· DDBJ | ADH92813.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |