Q58WW2 · DCAF6_HUMAN

  • Protein
    DDB1- and CUL4-associated factor 6
  • Gene
    DCAF6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCul4-RING E3 ubiquitin ligase complex
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentfocal adhesion
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionnuclear receptor coactivator activity
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DDB1- and CUL4-associated factor 6
  • Alternative names
    • Androgen receptor complex-associated protein (ARCAP)
    • IQ motif and WD repeat-containing protein 1
    • Nuclear receptor interaction protein (NRIP)

Gene names

    • Name
      DCAF6
    • Synonyms
      IQWD1
    • ORF names
      MSTP055

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q58WW2
  • Secondary accessions
    • A2A295
    • B4DNB8
    • Q7L8I0
    • Q8IXH3
    • Q8TB19

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_035020547in dbSNP:rs11558511

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 935 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00003044011-860UniProtDDB1- and CUL4-associated factor 6
Modified residue (large scale data)292PRIDEPhosphothreonine
Modified residue336UniProtPhosphoserine
Modified residue (large scale data)336PRIDEPhosphoserine
Modified residue (large scale data)467PRIDEPhosphoserine
Modified residue (large scale data)592PRIDEPhosphoserine
Modified residue649UniProtPhosphoserine
Modified residue (large scale data)649PRIDEPhosphoserine
Modified residue654UniProtPhosphothreonine
Modified residue (large scale data)654PRIDEPhosphothreonine
Modified residue657UniProtPhosphoserine
Modified residue (large scale data)657PRIDEPhosphoserine
Modified residue847UniProtPhosphoserine
Modified residue (large scale data)847PRIDEPhosphoserine
Modified residue850UniProtPhosphoserine
Modified residue (large scale data)850PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.

Binary interactions

View interactors in UniProtKB
View CPX-2784 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for repeat, compositional bias, region, domain.

TypeIDPosition(s)Description
Repeat49-88WD 1
Repeat92-133WD 2
Repeat139-179WD 3
Repeat189-229WD 4
Repeat251-290WD 5
Compositional bias288-335Basic and acidic residues
Region288-340Disordered
Region355-392Disordered
Compositional bias362-392Polar residues
Compositional bias407-446Polar residues
Region407-490Disordered
Compositional bias447-463Basic and acidic residues
Compositional bias502-533Polar residues
Region502-675Disordered
Compositional bias558-587Polar residues
Compositional bias612-645Polar residues
Domain676-705IQ
Repeat718-756WD 6
Repeat759-798WD 7

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q58WW2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    860
  • Mass (Da)
    96,292
  • Last updated
    2005-04-26 v1
  • Checksum
    8C7602D635DAF124
MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWNDTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVIFYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKEDCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGMVARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERREELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVAQSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQAHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLHYSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAPEESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESASSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDDPVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSRTMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSGIDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRADRLEGDRSEGSGQENENEDEE

Q58WW2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 459-459: S → SDSPSSVVNKQLGSMSLDEQQ

Q58WW2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 459-459: S → SEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQ
    • 675-675: D → DRFNIRGTTIGDRIM

Q58WW2-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 54-84: Missing
    • 459-459: S → SEFLRGPEIALLRKRLQQLRLKKAEQQRQQELAAHTQQQPSTSDQSSHEGSSQDPHASDSPSSVVNKQLGSMSLDEQQ
    • 675-675: D → DRFNIRGTTIGDRIM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F2Z305F2Z305_HUMANDCAF6472

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04331254-84in isoform 4
Compositional bias288-335Basic and acidic residues
Compositional bias362-392Polar residues
Compositional bias407-446Polar residues
Compositional bias447-463Basic and acidic residues
Alternative sequenceVSP_028019459in isoform 2
Alternative sequenceVSP_028020459in isoform 3 and isoform 4
Compositional bias502-533Polar residues
Compositional bias558-587Polar residues
Compositional bias612-645Polar residues
Alternative sequenceVSP_028021675in isoform 3 and isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY766164
EMBL· GenBank· DDBJ
AAX09330.1
EMBL· GenBank· DDBJ
mRNA
DQ768089
EMBL· GenBank· DDBJ
ABG76793.1
EMBL· GenBank· DDBJ
mRNA
AF116725
EMBL· GenBank· DDBJ
AAO15301.1
EMBL· GenBank· DDBJ
mRNA
AK297847
EMBL· GenBank· DDBJ
BAG60180.1
EMBL· GenBank· DDBJ
mRNA
Z97876
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL033531
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL031287
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL033532
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471067
EMBL· GenBank· DDBJ
EAW90809.1
EMBL· GenBank· DDBJ
Genomic DNA
BC025262
EMBL· GenBank· DDBJ
AAH25262.2
EMBL· GenBank· DDBJ
mRNA
AL136738
EMBL· GenBank· DDBJ
CAB66672.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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