Q58P21 · Q58P21_HUMAN

  • Protein
    Metalloproteinase inhibitor 1
  • Gene
    TIMP1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Features

Showing features for binding site.

118820406080100120140160180
TypeIDPosition(s)Description
Binding site24Zn2+ (UniProtKB | ChEBI); ligand shared with metalloproteinase partner

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functiongrowth factor activity
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase inhibitor activity
Biological Processnegative regulation of peptidase activity

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Metalloproteinase inhibitor 1
  • Alternative names
    • Tissue inhibitor of metalloproteinases 1

Gene names

    • Name
      TIMP1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q58P21

Subcellular Location

Secreted

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, disulfide bond, chain.

TypeIDPosition(s)Description
Signal1-23
Disulfide bond24↔90
ChainPRO_500425227024-188Metalloproteinase inhibitor 1
Disulfide bond26↔119
Disulfide bond36↔144
Disulfide bond152↔157
Disulfide bond165↔186

Keywords

Proteomic databases

Interaction

Subunit

Interacts with MMP1, MMP3, MMP10 and MMP13, but has only very low affinity for MMP14. Interacts with CD63; identified in a complex with CD63 and ITGB1.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain24-144NTR

Sequence similarities

Belongs to the protease inhibitor I35 (TIMP) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    188
  • Mass (Da)
    20,917
  • Last updated
    2005-04-26 v1
  • Checksum
    DCD275A33ADB6AC7
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYESKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLG

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue188

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY932824
EMBL· GenBank· DDBJ
AAX47478.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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