Q58NQ5 · PLAG1_CHICK
- ProteinZinc finger protein PLAG1
- GenePLAG1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids501 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytosol | |
Cellular Component | nuclear speck | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | gland morphogenesis | |
Biological Process | multicellular organism growth | |
Biological Process | negative regulation of gene expression | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of glial cell proliferation | |
Biological Process | prostate gland growth | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein PLAG1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ58NQ5
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000295110 | 1-501 | Zinc finger protein PLAG1 | ||
Proteomic databases
Expression
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, motif, zinc finger, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-30 | Disordered | |||
Motif | 22-25 | Nuclear localization signal | |||
Zinc finger | 34-56 | C2H2-type 1 | |||
Zinc finger | 62-86 | C2H2-type 2 | |||
Zinc finger | 92-114 | C2H2-type 3 | |||
Zinc finger | 121-143 | C2H2-type 4 | |||
Zinc finger | 150-172 | C2H2-type 5 | |||
Zinc finger | 185-207 | C2H2-type 6 | |||
Zinc finger | 213-236 | C2H2-type 7 | |||
Compositional bias | 366-383 | Polar residues | |||
Region | 366-406 | Disordered | |||
Region | 447-474 | Disordered | |||
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length501
- Mass (Da)55,958
- Last updated2005-04-26 v1
- ChecksumEB4E7A4AE8DB1E1A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 366-383 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY935990 EMBL· GenBank· DDBJ | AAX36028.1 EMBL· GenBank· DDBJ | mRNA |