Q58NQ5 · PLAG1_CHICK

  • Protein
    Zinc finger protein PLAG1
  • Gene
    PLAG1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Transcription factor and proto-oncogene whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation.

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentcytosol
Cellular Componentnuclear speck
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processgland morphogenesis
Biological Processmulticellular organism growth
Biological Processnegative regulation of gene expression
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of glial cell proliferation
Biological Processprostate gland growth
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein PLAG1
  • Alternative names
    • Pleiomorphic adenoma gene 1 protein

Gene names

    • Name
      PLAG1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q58NQ5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Variants

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The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002951101-501Zinc finger protein PLAG1

Proteomic databases

Expression

Tissue specificity

Expressed in nephroblastoma.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, motif, zinc finger, compositional bias.

Type
IDPosition(s)Description
Region1-30Disordered
Motif22-25Nuclear localization signal
Zinc finger34-56C2H2-type 1
Zinc finger62-86C2H2-type 2
Zinc finger92-114C2H2-type 3
Zinc finger121-143C2H2-type 4
Zinc finger150-172C2H2-type 5
Zinc finger185-207C2H2-type 6
Zinc finger213-236C2H2-type 7
Compositional bias366-383Polar residues
Region366-406Disordered
Region447-474Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    501
  • Mass (Da)
    55,958
  • Last updated
    2005-04-26 v1
  • Checksum
    EB4E7A4AE8DB1E1A
MATVIPGDLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCTQQDCTKAFVSKYKLLRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHNPNKEAFKCEECGKNYNTKLGFKRHLALHAATSGDLTCKVCLQTFESTGVLLEHLKTHAGKSSGGVKEKKHQCEHCDRRFYTRKDVRRHMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPMDLLDPFTCNVSVPIKDELLPVMSLPSSELTSKPFTNTLQLNLYNTQIQSMQSSASAHQMVATSLPLGMPCPIDMESVHPSHQLSLKYPLSSTSYAVSMPEKEQPLKGEIESYLMELQSGMPSSSQDSQASSSKLGLDPQVGPLDDGSGEVSLSKGSVPISEPLNTPSLDFSQLFNFIPVNGPPYNPSVSVGNLGMSYTQEEAHSSMTQLPPQTQDPQDPSNSIGLGSLHSLSAAFTSSLSTTTTLPRFHQAFQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias366-383Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY935990
EMBL· GenBank· DDBJ
AAX36028.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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