Diagnostic value of glycophorin-A in comparison with P57 immunohistochemical staining method in differentiating complete and partial molar pregnancies.
These results are consistent with malaria acting as a selective pressure on GYPA but also suggest that another selective force has resulted in a similar pattern of variation in Europeans. Accordingly GYPA has perhaps a more complex evolutionary history wherein on a global scale spatially varying selective pressures have governed its natural history.
Cell viability and surface expression of transferrin receptor (CD71) and glycophorin A (GPA) were analyzed before and after re-culture by flow cytometry. These studies show differential sensitivities of these surface proteins on K562 cells to proteases and suggest molecular mechanisms of transmembrane protein transport and cycling.
a complex structural rearrangement involving the loss of GYPB and gain of two GYPB-A hybrid genes reduces the risk of severe malaria by 40% and has recently increased in frequency in parts of Kenya
The authors show that Plasmodium falciparum EBA-175 mediates substantial changes in the deformability of erythrocytes by binding to glycophorin A and activating a phosphorylation cascade that includes erythrocyte cytoskeletal proteins resulting in changes in the viscoelastic properties of the host cell.
While weak interactions between glycophorin and band 3 undoubtedly exist glycophorin A and band 3 must have separate interactions in the membrane that control their lateral mobility.
Glycophorin-A-rich microparticles are released from evolving growing thrombi into the distal perfusing blood and can be measured in peripheral blood. CD235a(+) cMPs may constitute a novel systemic biomarker of ongoing thrombosis.
The authors demonstrate that the initial vacuolar membrane around internalized Babesia divergens is formed from protein and lipid components of the red blood cells plasma membrane including band 3 glycophorin A and spectrin.
These data demonstrate the importance of PfEBA175 regions other than the DBL domains in the interaction with GYPA and merit their inclusion in an EBA175-based vaccine.
The expression of glycophorin A and osteoprotegerin is locally increased in carotid atherosclerotic lesions of symptomatic compared to asymptomatic patients.
Data suggest that glycophorin A (Gpa) increases expression and activity of Cl-/HCO3- exchanger Ae1 that G719D mutation renders Ae1 mutant constructs GPA-unresponsive and suggests a role for Ae1 amino acids 22-28 in GPA responsiveness.
the GG genotype of the rs 1489759 HHIP single-nucleotide polymorphism (SNP) and the CC genotype of the rs 2202507 GYPA SNP confers a ''protective'' effect on COPD (OR 0.59 p50.006 for HHIP and OR50.65 p50.006 for GYPA) and lung cancer.
Data indicate that changes of the glycophorin A dimerization propensities in different lipid bilayers suggest that the lipid bilayer thickness severely influences the monomer-dimer equilibrium of the transmembrane domain.
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