Q585M6 · Q585M6_TRYB2
- ProteinSulfhydryl oxidase
- GeneTb06.28P18.860
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids526 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 313 | FAD (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 320 | FAD (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 356 | FAD (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 373 | FAD (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 376 | FAD (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 377 | FAD (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 380 | FAD (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 382 | FAD (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 396 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 399 | FAD (UniProtKB | ChEBI) | ||||
Sequence: F |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Molecular Function | flavin-dependent sulfhydryl oxidase activity | |
Molecular Function | nucleotide binding | |
Molecular Function | protein disulfide isomerase activity | |
Molecular Function | thiol oxidase activity | |
Biological Process | protein folding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfhydryl oxidase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma
Accessions
- Primary accessionQ585M6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 490-513 | Helical | ||||
Sequence: GYSVLLFSNVFIILLFVCLGSFDY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MFSRSFVVFAGLLCCCLSKSVA | ||||||
Chain | PRO_5010681848 | 23-526 | Sulfhydryl oxidase | |||
Sequence: QVATGSPRPGLFHLDSSVVDLSGDDFSRVHRVAPLCPWIVLFYNDGCGACRRYASTFSKFAGGLKVEHGKDALQIATAAAVNCASEVDLCRKYDINFVPRLFFFYPRDSCRSNEECGTSSLEHVAFENSHLEVDELESEVRRLVNKHMVVDDSLKERCIDMHFKLYTSKEELVKRSVSSTDESGRFVETTELYATDIAGAFFSAMHYDVSLVGTEPRERLTALEDFVLLVKDSLPSIGADGVVSALESITAERPFTVASWQDAVVKSGIPFDGSPRNVRWRTCRGSSPQYRGFPCGMWLLLHALTVNTPADRNVLEVIQNYIRYFFSCKECRDHFIQFNFSPNEDPVLQLWRAHNNVNARLANVKDGADPLVPKRQFPTLEACTECYDGAGNFIEAHVTGFLKQRYLWDPKAVGLMESNDDLNEVDPASKDANVGRNVESSGKGKGDGGARGNSKEVRSDHAGGKGKGYSVLLFSNVFIILLFVCLGSFDYMKRLRVRKRRDRY | ||||||
Disulfide bond | 58↔180 | |||||
Sequence: CPWIVLFYNDGCGACRRYASTFSKFAGGLKVEHGKDALQIATAAAVNCASEVDLCRKYDINFVPRLFFFYPRDSCRSNEECGTSSLEHVAFENSHLEVDELESEVRRLVNKHMVVDDSLKERC | ||||||
Disulfide bond | 69↔72 | |||||
Sequence: CGAC | ||||||
Disulfide bond | 69↔350 | |||||
Sequence: CGACRRYASTFSKFAGGLKVEHGKDALQIATAAAVNCASEVDLCRKYDINFVPRLFFFYPRDSCRSNEECGTSSLEHVAFENSHLEVDELESEVRRLVNKHMVVDDSLKERCIDMHFKLYTSKEELVKRSVSSTDESGRFVETTELYATDIAGAFFSAMHYDVSLVGTEPRERLTALEDFVLLVKDSLPSIGADGVVSALESITAERPFTVASWQDAVVKSGIPFDGSPRNVRWRTCRGSSPQYRGFPCGMWLLLHALTVNTPADRNVLEVIQNYIRYFFSC | ||||||
Disulfide bond | 105↔112 | |||||
Sequence: CASEVDLC | ||||||
Disulfide bond | 132↔138 | |||||
Sequence: CRSNEEC | ||||||
Disulfide bond | 305↔317 | |||||
Sequence: CRGSSPQYRGFPC | ||||||
Disulfide bond | 350↔353 | |||||
Sequence: CKEC | ||||||
Disulfide bond | 405↔408 | |||||
Sequence: CTEC |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 29-167 | Thioredoxin | ||||
Sequence: PRPGLFHLDSSVVDLSGDDFSRVHRVAPLCPWIVLFYNDGCGACRRYASTFSKFAGGLKVEHGKDALQIATAAAVNCASEVDLCRKYDINFVPRLFFFYPRDSCRSNEECGTSSLEHVAFENSHLEVDELESEVRRLVN | ||||||
Domain | 308-398 | ERV/ALR sulfhydryl oxidase | ||||
Sequence: SSPQYRGFPCGMWLLLHALTVNTPADRNVLEVIQNYIRYFFSCKECRDHFIQFNFSPNEDPVLQLWRAHNNVNARLANVKDGADPLVPKRQ | ||||||
Region | 445-485 | Disordered | ||||
Sequence: NEVDPASKDANVGRNVESSGKGKGDGGARGNSKEVRSDHAG | ||||||
Compositional bias | 471-485 | Basic and acidic residues | ||||
Sequence: GARGNSKEVRSDHAG |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length526
- Mass (Da)58,755
- Last updated2005-05-10 v1
- Checksum1568620DF684FF97
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 471-485 | Basic and acidic residues | ||||
Sequence: GARGNSKEVRSDHAG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC013353 EMBL· GenBank· DDBJ | AAX79709.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP000069 EMBL· GenBank· DDBJ | AAZ11747.1 EMBL· GenBank· DDBJ | Genomic DNA |