MiR-145 exerted a protective effects in cell viability in the OGD model by downregulating EPHA4 which suggested their potential roles in ischemic stroke.
EPHA4 signaling might function to maintain homeostasis of vascular smooth muscle cell contractility and BP in a fine-tuning capacity for which estrogen is an effective modifier.
blockage of EphA4/ephrin signaling between neuron and microglia decreased in oxygen-glucose deprivation and reperfusion -induced injury by promoting alternative activation of microglia via RhoA/ROCK2 signaling.
Therefore EphA4 is an emerging AbetaOs receptor and the activation of the EphA4/c-Abl axis would explain the synaptic spine alterations found in Alzheimer's disease.
our data revealed a strong association between high EPHA4 expression and advanced tumor stage aggressive BLBC molecular subtype and poor prognosis. Importantly we found significant co-expression of EPHA4 and the TGFbeta receptor type-2 (TGFbetaR2) in breast cancer subtypes associated with increased tumor relapse and drug resistance.
These findings confirmed that EphA4 is a direct target gene of miR-335 and that miR-335 suppresses breast cancer cell proliferation and motility in part by directly inhibiting EphA4 expression.
we supposed that EphA4 interacted with CDK5 and promoted its expression which in turn enhanced p-AKT expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.
Findings demonstrated that mutant alpha2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant alpha2-chimaerin to direct growth while cervical spinal neurons use only ephrin forward signaling
The expression of both EphA4-FL and EphA4-N was significantly higher in the nervous tissue of SOD1(G93A) compared to wild-type mice suggesting that both forms are modulated during the disease process.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.