Q57ZY1 · Q57ZY1_TRYB2

Function

Catalytic activity

  • NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+.
    EC:2.4.2.30 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular FunctionNAD+-protein ADP-ribosyltransferase activity
Molecular FunctionNAD+-protein poly-ADP-ribosyltransferase activity
Molecular Functionnucleotidyltransferase activity
Biological Processdouble-strand break repair
Biological Processprotein poly-ADP-ribosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Poly [ADP-ribose] polymerase
  • EC number
  • Short names
    PARP

Gene names

    • Name
      Tb05.26K5.30
    • ORF names
      Tb927.5.3050

Organism names

Accessions

  • Primary accession
    Q57ZY1
  • Secondary accessions
    • D6XGP1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-48Disordered
Compositional bias7-21Polar residues
Compositional bias32-48Polar residues
Domain101-197WGR
Region204-230Disordered
Compositional bias212-230Basic and acidic residues
Domain229-344PARP alpha-helical
Domain352-573PARP catalytic

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    573
  • Mass (Da)
    65,235
  • Last updated
    2005-05-10 v1
  • Checksum
    CF141B5623215B7C
MAAKGKSTQRRSATGGANSKGASAKISPVKKSTARKGQQKTTKKTPVVTKPVPTKTTAAAGVKKKVDAAVTTQAPVTGGKRERFLRKGRGVVDVHSGKVDTCHVYERDGTVFQFTLNQTNISSNNNKFYITQLLEDDARKNYFIFARWGRVGAVGQYMLEPYLDARSAEQDFCSKFREKTRNDWVDRGRFKKVPGKYEYMEVDYGEDDDDDAGGEKPGKKKKAEKPVRESKLPKEVQDLMRLIGCRESMSQVLRELEVDTERMPLGKISKAQILRAYEVLKEIEKKLKRPLKQLEELSSRFYTLIPHAFGTRRPPVINTVDVVRQKREMLETLAELEVASTLVDMKDDEALHPLDNIYRKMKCAIQPLKPQSEVYKRIVQYVRNTQGPTHDAYTLQVVEVFTLRREDEEERYKPFKKMDNRQMLWHGSRITNFLGILSQGLRIAPPEAPCTGYMFGKGIYLSDVCSKSANYCHPPRDTNTGLLLLCEVALGKQKEYENAHYMLEPEKGTNSTKGVGRMYPDPKGAEVVKGVLWPKGCIKEDSRSTSLIYPEHIIYDVRQCVLRYLVRVSFEYK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias7-21Polar residues
Compositional bias32-48Polar residues
Compositional bias212-230Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC104488
EMBL· GenBank· DDBJ
AAX79344.1
EMBL· GenBank· DDBJ
Genomic DNA
CP000068
EMBL· GenBank· DDBJ
AAZ11418.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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