Q57V41 · SIR2_TRYB2

Function

function

NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site37-57NAD+ (UniProtKB | ChEBI)
Binding site122-125NAD+ (UniProtKB | ChEBI)
Active site142Proton acceptor
Binding site150Zn2+ (UniProtKB | ChEBI)
Binding site153Zn2+ (UniProtKB | ChEBI)
Binding site174Zn2+ (UniProtKB | ChEBI)
Binding site177Zn2+ (UniProtKB | ChEBI)
Binding site213-215NAD+ (UniProtKB | ChEBI)
Binding site238-240NAD+ (UniProtKB | ChEBI)
Binding site311NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD+ ADP-ribosyltransferase activity
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacetylase SIR2rp1
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog 1
    • SIR2-related protein 1

Gene names

    • Name
      SIR2rp1
    • Synonyms
      SIR2
    • ORF names
      Tb927.7.1690

Organism names

Accessions

  • Primary accession
    Q57V41
  • Secondary accessions
    • D6XK87
    • O96670

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis142Abolishes enzyme activity.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004174071-351NAD-dependent protein deacetylase SIR2rp1

Proteomic databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q57V41H1-1 Q025392EBI-7579996, EBI-932603
XENO Q57V41H1-2 P022537EBI-7579996, EBI-7580031

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain10-325Deacetylase sirtuin-type
Region260-284Disordered

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    38,575
  • Last updated
    2005-05-10 v1
  • Checksum
    046B99AAC661D650
MTEPKLATTHVVGEPTFEGLARFIERNNITKIFVMVGAGISVAAGIPDFRSPHTGLYAKLSRYNLNSPEDAFSLPLLRQQPSVFYNILMDMDLWPGKYCPTTVHHFISLLAKKGMLLCCCTQNIDGLERACGIPESLLVEAHGSFSSASCVDCHAKYDINMARAETRAGKVPHCNQCGGIVKPDVVFFGENLPEAFFNVAGLIEETELLLILGTSLQVHPFADLALMVPSDVPRVLFNLERVGGRMFRFPTDRTPNFRASSYRLSTGNGNGSKISSGDSSNSSSVDGYDQFTLAENDETGVLRDIFFPGDCQVSVRSFAQALGFGEQLDASVREGREIFERTRRREKVVEG

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict161in Ref. 1; AAC73004
Sequence conflict281in Ref. 1; AAC73004

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF102869
EMBL· GenBank· DDBJ
AAC73004.1
EMBL· GenBank· DDBJ
Genomic DNA
AC159447
EMBL· GenBank· DDBJ
AAX70528.1
EMBL· GenBank· DDBJ
Genomic DNA
CP000070
EMBL· GenBank· DDBJ
AAZ12234.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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