Q57I19 · CCMAE_SALCH
- ProteinPutative bifunctional cytochrome c-type biogenesis protein CcmAE
- GeneccmAE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids336 (go to sequence)
- Protein existenceUncertain
- Annotation score4/5
Function
function
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity).
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity).
Catalytic activity
- ATP + H2O + heme b(in) = ADP + H+ + heme b(out) + phosphate
CHEBI:30616 + CHEBI:15377 + heme b (in)CHEBI:60344= CHEBI:456216 + CHEBI:15378 + heme b (out)CHEBI:60344+ CHEBI:43474
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ABC-type heme transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | cytochrome complex assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended namePutative bifunctional cytochrome c-type biogenesis protein CcmAE
Including 2 domains:
- Recommended nameCytochrome c biogenesis ATP-binding export protein CcmA 2
- EC number
- Alternative names
- Recommended nameCytochrome c-type biogenesis protein CcmE 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella
Accessions
- Primary accessionQ57I19
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000238860 | 1-336 | Putative bifunctional cytochrome c-type biogenesis protein CcmAE | |||
Sequence: MLEARDLYCERDERTLFRGLSFTVDAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTTALVLYALRANIDLFYTPGEILYGKRETQQLPAVGQRLRVGGMVMPGSVRRDPDSLKVNFSLYDAEGSVTVSYEGILPDLFREGQGVVVQGTLEKGNHVLAHEVLAKHDENYTPPEVEKAMQENHRRPQRVDKDTSS |
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-199 | Cytochrome c biogenesis ATP-binding export protein CcmA 2 | ||||
Sequence: MLEARDLYCERDERTLFRGLSFTVDAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALT | ||||||
Domain | 2-242 | ABC transporter | ||||
Sequence: LEARDLYCERDERTLFRGLSFTVDAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHRSLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTTALVLYALRANIDLFYTPGEILYGKRETQQLPAVGQRLRVGGM | ||||||
Region | 196-336 | Cytochrome c-type biogenesis protein CcmE 2 | ||||
Sequence: LALTTALVLYALRANIDLFYTPGEILYGKRETQQLPAVGQRLRVGGMVMPGSVRRDPDSLKVNFSLYDAEGSVTVSYEGILPDLFREGQGVVVQGTLEKGNHVLAHEVLAKHDENYTPPEVEKAMQENHRRPQRVDKDTSS | ||||||
Region | 307-336 | Disordered | ||||
Sequence: HDENYTPPEVEKAMQENHRRPQRVDKDTSS |
Sequence similarities
In the N-terminal section; belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
In the C-terminal section; belongs to the CcmE/CycJ family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length336
- Mass (Da)37,197
- Last updated2006-05-30 v2
- Checksum26E359D6F50FB952
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017220 EMBL· GenBank· DDBJ | AAX67643.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |