Q571N9 · Q571N9_MOUSE
- ProteinMFLJ00163 protein
- GeneMaged1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids798 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q571N9
The deficiency of Maged1 attenuates Parkinson's disease progression in mice.
- AnnotationThe deficiency of Maged1 attenuates Parkinson's disease progression in mice.
- CategoriesFunction, Expression
- SourceGeneRif: 94275
A potential role of <i>p75NTR</i> in the regulation of circadian rhythm and incremental growth lines during tooth development.
- CategoriesFunction, Expression
- SourceMGI: 1930187
Knockdown of Maged1 inhibits cell cycle progression and causes cell death in mouse embryonic stem cells.
- AnnotationKnockdown of Maged1 inhibits cell cycle progression and causes cell death in mouse embryonic stem cells.
- CategoriesFunction, Expression
- SourceGeneRif: 94275
The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1930187
Inhibition of PPARgamma, adipogenesis and insulin sensitivity by MAGED1.
- Annotationnegative regulator of PPARgamma activity adipogenesis and insulin sensitivity
- CategoryFunction
- SourceGeneRif: 94275
Deletion of <i>Maged1</i> in mice abolishes locomotor and reinforcing effects of cocaine.
- AnnotationThis work identifies Maged1 as a critical molecule involved in cellular processes and behaviours related to addiction.
- CategoriesFunction, Phenotypes & Variants
Knockdown of NRAGE induces odontogenic differentiation by activating NF- kappaB signaling in mouse odontoblast-like cells.
- AnnotationNRAGE is an important regulator of odontogenic differentiation of odontoblasts by inhibiting the NF-kappaB signaling pathway through binding to IKKbeta.
- CategoryInteraction
- SourceGeneRif: 94275
Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
- AnnotationBoth transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation.
- CategoriesFunction, Expression, Interaction
- SourceGeneRif: 94275
MAGED1 is a negative regulator of bone remodeling in mice.
- AnnotationMAGED1 as a novel regulator of osteoblastogenesis osteoclastogenesis and bone remodeling in a mouse model
- CategoryFunction
Effects of neurotrophin receptor-mediated MAGE homology on proliferation and odontoblastic differentiation of mouse dental pulp cells.
- AnnotationNRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells which might be via the NF-kappaB signalling pathway.
- CategoryInteraction
- SourceGeneRif: 94275
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
- CategoriesSequences, Expression
- SourceMGI: 1930187
Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
- CategoryInteraction
- SourceMGI: 1930187
Maged1 co-interacting with CREB through a hexapeptide repeat domain regulates learning and memory in mice.
- AnnotationMaged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB).
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 94275
Systems genetic analysis of osteoblast-lineage cells.
- AnnotationMaged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD)
- CategoriesNames, Expression
Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE.
- AnnotationShow Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE.
- CategoriesFunction, Interaction
- SourceGeneRif: 94275
Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus.
- AnnotationWe conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes
- CategoriesFunction, Phenotypes & Variants
MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation.
- Annotationthe present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation.
- CategoriesFunction, Phenotypes & Variants
A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1- TAK1 signaling for NF-kappaB activation and apoptosis in P19 cells.
- AnnotationXIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation.
- CategoriesFunction, Interaction
- SourceGeneRif: 94275
A conditional knockout resource for the genome-wide study of mouse gene function.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 1930187
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
- CategoryExpression
- SourceMGI: 1930187