Q571K9 · Q571K9_MOUSE
- ProteinPhosphoinositide phospholipase C
- GenePlcb3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1048 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 367 | ||||
Binding site | 368 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 397 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 399 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 414 | ||||
Binding site | 448 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoinositide phospholipase C
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ571K9
Organism-specific databases
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-30 | Disordered | |||
Region | 501-623 | Disordered | |||
Compositional bias | 519-554 | Polar residues | |||
Domain | 626-742 | PI-PLC Y-box | |||
Domain | 743-871 | C2 | |||
Compositional bias | 923-938 | Polar residues | |||
Region | 923-973 | Disordered | |||
Compositional bias | 939-955 | Pro residues | |||
Compositional bias | 956-973 | Polar residues | |||
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,048
- Mass (Da)117,162
- Last updated2005-05-10 v1
- ChecksumE7B8433C7C3AA3FE
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 519-554 | Polar residues | |||
Compositional bias | 923-938 | Polar residues | |||
Compositional bias | 939-955 | Pro residues | |||
Compositional bias | 956-973 | Polar residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK220180 EMBL· GenBank· DDBJ | BAD90365.1 EMBL· GenBank· DDBJ | mRNA |