Q56PW6 · Q56PW6_9CARA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • P001
    • P002
    • P003
    • P004
    • P005
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Carabinae > Carabini > Carabina > Carabus > Coptolabrus

Accessions

  • Primary accession
    Q56PW6

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane36-62Helical
Transmembrane74-101Helical
Transmembrane121-142Helical
Transmembrane163-182Helical
Transmembrane194-217Helical
Transmembrane229-250Helical
Transmembrane270-291Helical

Keywords

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-294Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    294
  • Mass (Da)
    31,669
  • Last updated
    2005-05-10 v1
  • Checksum
    04957E70E996528C
TLLLMSSMVESGAGTGWTVYPPLSASIAHGGASVDLAIFSLHLAGISSILGAVNFITTIINMRSVGMTFDRMPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISSESGKKETFGSLGMIYAMLAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGAQISYSPSLLWALGFVFLFTVGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFAILAGFIQWFPLFTGL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue294

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY840838
EMBL· GenBank· DDBJ
AAW28402.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840839
EMBL· GenBank· DDBJ
AAW28403.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840841
EMBL· GenBank· DDBJ
AAW28405.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840842
EMBL· GenBank· DDBJ
AAW28406.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840846
EMBL· GenBank· DDBJ
AAW28410.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840847
EMBL· GenBank· DDBJ
AAW28411.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840848
EMBL· GenBank· DDBJ
AAW28412.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840849
EMBL· GenBank· DDBJ
AAW28413.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840850
EMBL· GenBank· DDBJ
AAW28414.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840851
EMBL· GenBank· DDBJ
AAW28415.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840854
EMBL· GenBank· DDBJ
AAW28418.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840855
EMBL· GenBank· DDBJ
AAW28419.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840857
EMBL· GenBank· DDBJ
AAW28421.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840858
EMBL· GenBank· DDBJ
AAW28422.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840859
EMBL· GenBank· DDBJ
AAW28423.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840861
EMBL· GenBank· DDBJ
AAW28425.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840862
EMBL· GenBank· DDBJ
AAW28426.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840863
EMBL· GenBank· DDBJ
AAW28427.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840864
EMBL· GenBank· DDBJ
AAW28428.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840865
EMBL· GenBank· DDBJ
AAW28429.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840866
EMBL· GenBank· DDBJ
AAW28430.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840869
EMBL· GenBank· DDBJ
AAW28433.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840870
EMBL· GenBank· DDBJ
AAW28434.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840871
EMBL· GenBank· DDBJ
AAW28435.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840872
EMBL· GenBank· DDBJ
AAW28436.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840873
EMBL· GenBank· DDBJ
AAW28437.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840874
EMBL· GenBank· DDBJ
AAW28438.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840875
EMBL· GenBank· DDBJ
AAW28439.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840876
EMBL· GenBank· DDBJ
AAW28440.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840877
EMBL· GenBank· DDBJ
AAW28441.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840878
EMBL· GenBank· DDBJ
AAW28442.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840879
EMBL· GenBank· DDBJ
AAW28443.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840880
EMBL· GenBank· DDBJ
AAW28444.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840881
EMBL· GenBank· DDBJ
AAW28445.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840882
EMBL· GenBank· DDBJ
AAW28446.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840887
EMBL· GenBank· DDBJ
AAW28451.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840888
EMBL· GenBank· DDBJ
AAW28452.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840889
EMBL· GenBank· DDBJ
AAW28453.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840890
EMBL· GenBank· DDBJ
AAW28454.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840892
EMBL· GenBank· DDBJ
AAW28456.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840893
EMBL· GenBank· DDBJ
AAW28457.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840894
EMBL· GenBank· DDBJ
AAW28458.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840895
EMBL· GenBank· DDBJ
AAW28459.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840896
EMBL· GenBank· DDBJ
AAW28460.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840897
EMBL· GenBank· DDBJ
AAW28461.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840898
EMBL· GenBank· DDBJ
AAW28462.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840899
EMBL· GenBank· DDBJ
AAW28463.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840900
EMBL· GenBank· DDBJ
AAW28464.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840901
EMBL· GenBank· DDBJ
AAW28465.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840902
EMBL· GenBank· DDBJ
AAW28466.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840903
EMBL· GenBank· DDBJ
AAW28467.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840904
EMBL· GenBank· DDBJ
AAW28468.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840905
EMBL· GenBank· DDBJ
AAW28469.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840906
EMBL· GenBank· DDBJ
AAW28470.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840907
EMBL· GenBank· DDBJ
AAW28471.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840908
EMBL· GenBank· DDBJ
AAW28472.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840909
EMBL· GenBank· DDBJ
AAW28473.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840911
EMBL· GenBank· DDBJ
AAW28475.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840912
EMBL· GenBank· DDBJ
AAW28476.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840913
EMBL· GenBank· DDBJ
AAW28477.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840914
EMBL· GenBank· DDBJ
AAW28478.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840915
EMBL· GenBank· DDBJ
AAW28479.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840916
EMBL· GenBank· DDBJ
AAW28480.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840917
EMBL· GenBank· DDBJ
AAW28481.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840918
EMBL· GenBank· DDBJ
AAW28482.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840919
EMBL· GenBank· DDBJ
AAW28483.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840920
EMBL· GenBank· DDBJ
AAW28484.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840921
EMBL· GenBank· DDBJ
AAW28485.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840923
EMBL· GenBank· DDBJ
AAW28487.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840924
EMBL· GenBank· DDBJ
AAW28488.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840925
EMBL· GenBank· DDBJ
AAW28489.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840926
EMBL· GenBank· DDBJ
AAW28490.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840927
EMBL· GenBank· DDBJ
AAW28491.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840928
EMBL· GenBank· DDBJ
AAW28492.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840929
EMBL· GenBank· DDBJ
AAW28493.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840930
EMBL· GenBank· DDBJ
AAW28494.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840931
EMBL· GenBank· DDBJ
AAW28495.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840932
EMBL· GenBank· DDBJ
AAW28496.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840933
EMBL· GenBank· DDBJ
AAW28497.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840934
EMBL· GenBank· DDBJ
AAW28498.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840935
EMBL· GenBank· DDBJ
AAW28499.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840937
EMBL· GenBank· DDBJ
AAW28501.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840938
EMBL· GenBank· DDBJ
AAW28502.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840939
EMBL· GenBank· DDBJ
AAW28503.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840940
EMBL· GenBank· DDBJ
AAW28504.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840941
EMBL· GenBank· DDBJ
AAW28505.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840942
EMBL· GenBank· DDBJ
AAW28506.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840943
EMBL· GenBank· DDBJ
AAW28507.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840944
EMBL· GenBank· DDBJ
AAW28508.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840945
EMBL· GenBank· DDBJ
AAW28509.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840946
EMBL· GenBank· DDBJ
AAW28510.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840947
EMBL· GenBank· DDBJ
AAW28511.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840948
EMBL· GenBank· DDBJ
AAW28512.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840949
EMBL· GenBank· DDBJ
AAW28513.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840950
EMBL· GenBank· DDBJ
AAW28514.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840952
EMBL· GenBank· DDBJ
AAW28516.1
EMBL· GenBank· DDBJ
Genomic DNA
AY840954
EMBL· GenBank· DDBJ
AAW28518.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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