Q56PW6 · Q56PW6_9CARA
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids294 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Adephaga > Caraboidea > Carabidae > Carabinae > Carabini > Carabina > Carabus > Coptolabrus
Accessions
- Primary accessionQ56PW6
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 36-62 | Helical | ||||
Sequence: LAIFSLHLAGISSILGAVNFITTIINM | ||||||
Transmembrane | 74-101 | Helical | ||||
Sequence: LFVWSVGITALLLLLSLPVLAGAITMLL | ||||||
Transmembrane | 121-142 | Helical | ||||
Sequence: LYQHLFWFFGHPEVYILILPGF | ||||||
Transmembrane | 163-182 | Helical | ||||
Sequence: GMIYAMLAIGLLGFVVWAHH | ||||||
Transmembrane | 194-217 | Helical | ||||
Sequence: AYFTSATMIIAVPTGIKIFSWLAT | ||||||
Transmembrane | 229-250 | Helical | ||||
Sequence: LLWALGFVFLFTVGGLTGVVLA | ||||||
Transmembrane | 270-291 | Helical | ||||
Sequence: YVLSMGAVFAILAGFIQWFPLF |
Keywords
- Cellular component
Interaction
Subunit
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-294 | Cytochrome oxidase subunit I profile | ||||
Sequence: TLLLMSSMVESGAGTGWTVYPPLSASIAHGGASVDLAIFSLHLAGISSILGAVNFITTIINMRSVGMTFDRMPLFVWSVGITALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISSESGKKETFGSLGMIYAMLAIGLLGFVVWAHHMFTVGMDVDTRAYFTSATMIIAVPTGIKIFSWLATLHGAQISYSPSLLWALGFVFLFTVGGLTGVVLANSSIDIILHDTYYVVAHFHYVLSMGAVFAILAGFIQWFPLFTGL |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length294
- Mass (Da)31,669
- Last updated2005-05-10 v1
- Checksum04957E70E996528C
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: T | ||||||
Non-terminal residue | 294 | |||||
Sequence: L |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY840838 EMBL· GenBank· DDBJ | AAW28402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840839 EMBL· GenBank· DDBJ | AAW28403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840841 EMBL· GenBank· DDBJ | AAW28405.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840842 EMBL· GenBank· DDBJ | AAW28406.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840846 EMBL· GenBank· DDBJ | AAW28410.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840847 EMBL· GenBank· DDBJ | AAW28411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840848 EMBL· GenBank· DDBJ | AAW28412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840849 EMBL· GenBank· DDBJ | AAW28413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840850 EMBL· GenBank· DDBJ | AAW28414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840851 EMBL· GenBank· DDBJ | AAW28415.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840854 EMBL· GenBank· DDBJ | AAW28418.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840855 EMBL· GenBank· DDBJ | AAW28419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840857 EMBL· GenBank· DDBJ | AAW28421.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840858 EMBL· GenBank· DDBJ | AAW28422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840859 EMBL· GenBank· DDBJ | AAW28423.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840861 EMBL· GenBank· DDBJ | AAW28425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840862 EMBL· GenBank· DDBJ | AAW28426.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840863 EMBL· GenBank· DDBJ | AAW28427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840864 EMBL· GenBank· DDBJ | AAW28428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840865 EMBL· GenBank· DDBJ | AAW28429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840866 EMBL· GenBank· DDBJ | AAW28430.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840869 EMBL· GenBank· DDBJ | AAW28433.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840870 EMBL· GenBank· DDBJ | AAW28434.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840871 EMBL· GenBank· DDBJ | AAW28435.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840872 EMBL· GenBank· DDBJ | AAW28436.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840873 EMBL· GenBank· DDBJ | AAW28437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840874 EMBL· GenBank· DDBJ | AAW28438.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840875 EMBL· GenBank· DDBJ | AAW28439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840876 EMBL· GenBank· DDBJ | AAW28440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840877 EMBL· GenBank· DDBJ | AAW28441.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840878 EMBL· GenBank· DDBJ | AAW28442.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840879 EMBL· GenBank· DDBJ | AAW28443.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840880 EMBL· GenBank· DDBJ | AAW28444.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840881 EMBL· GenBank· DDBJ | AAW28445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840882 EMBL· GenBank· DDBJ | AAW28446.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840887 EMBL· GenBank· DDBJ | AAW28451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840888 EMBL· GenBank· DDBJ | AAW28452.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840889 EMBL· GenBank· DDBJ | AAW28453.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840890 EMBL· GenBank· DDBJ | AAW28454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840892 EMBL· GenBank· DDBJ | AAW28456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840893 EMBL· GenBank· DDBJ | AAW28457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840894 EMBL· GenBank· DDBJ | AAW28458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840895 EMBL· GenBank· DDBJ | AAW28459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840896 EMBL· GenBank· DDBJ | AAW28460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840897 EMBL· GenBank· DDBJ | AAW28461.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840898 EMBL· GenBank· DDBJ | AAW28462.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840899 EMBL· GenBank· DDBJ | AAW28463.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840900 EMBL· GenBank· DDBJ | AAW28464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840901 EMBL· GenBank· DDBJ | AAW28465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840902 EMBL· GenBank· DDBJ | AAW28466.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840903 EMBL· GenBank· DDBJ | AAW28467.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840904 EMBL· GenBank· DDBJ | AAW28468.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840905 EMBL· GenBank· DDBJ | AAW28469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840906 EMBL· GenBank· DDBJ | AAW28470.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840907 EMBL· GenBank· DDBJ | AAW28471.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840908 EMBL· GenBank· DDBJ | AAW28472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840909 EMBL· GenBank· DDBJ | AAW28473.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840911 EMBL· GenBank· DDBJ | AAW28475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840912 EMBL· GenBank· DDBJ | AAW28476.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840913 EMBL· GenBank· DDBJ | AAW28477.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840914 EMBL· GenBank· DDBJ | AAW28478.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840915 EMBL· GenBank· DDBJ | AAW28479.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840916 EMBL· GenBank· DDBJ | AAW28480.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840917 EMBL· GenBank· DDBJ | AAW28481.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840918 EMBL· GenBank· DDBJ | AAW28482.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840919 EMBL· GenBank· DDBJ | AAW28483.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840920 EMBL· GenBank· DDBJ | AAW28484.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840921 EMBL· GenBank· DDBJ | AAW28485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840923 EMBL· GenBank· DDBJ | AAW28487.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840924 EMBL· GenBank· DDBJ | AAW28488.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840925 EMBL· GenBank· DDBJ | AAW28489.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840926 EMBL· GenBank· DDBJ | AAW28490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840927 EMBL· GenBank· DDBJ | AAW28491.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840928 EMBL· GenBank· DDBJ | AAW28492.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840929 EMBL· GenBank· DDBJ | AAW28493.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840930 EMBL· GenBank· DDBJ | AAW28494.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840931 EMBL· GenBank· DDBJ | AAW28495.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840932 EMBL· GenBank· DDBJ | AAW28496.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840933 EMBL· GenBank· DDBJ | AAW28497.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840934 EMBL· GenBank· DDBJ | AAW28498.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840935 EMBL· GenBank· DDBJ | AAW28499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840937 EMBL· GenBank· DDBJ | AAW28501.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840938 EMBL· GenBank· DDBJ | AAW28502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840939 EMBL· GenBank· DDBJ | AAW28503.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840940 EMBL· GenBank· DDBJ | AAW28504.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840941 EMBL· GenBank· DDBJ | AAW28505.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840942 EMBL· GenBank· DDBJ | AAW28506.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840943 EMBL· GenBank· DDBJ | AAW28507.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840944 EMBL· GenBank· DDBJ | AAW28508.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840945 EMBL· GenBank· DDBJ | AAW28509.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840946 EMBL· GenBank· DDBJ | AAW28510.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840947 EMBL· GenBank· DDBJ | AAW28511.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840948 EMBL· GenBank· DDBJ | AAW28512.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840949 EMBL· GenBank· DDBJ | AAW28513.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840950 EMBL· GenBank· DDBJ | AAW28514.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840952 EMBL· GenBank· DDBJ | AAW28516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY840954 EMBL· GenBank· DDBJ | AAW28518.1 EMBL· GenBank· DDBJ | Genomic DNA |