Cenpj rgulates clia dsassembly and nurogenesis in the developing mouse cortex. Results illustrate that Cenpj regulates cilia disassembly and neurogenesis through Kif2a indicating that primary cilia dynamics play a crucial role in NPC mitosis and adult neurogenesis.
Data suggest that alcohol/ethanol exposure diminishes pool of proliferative neurons (Neuro2a cell line) through disordering of spindle orientation and promotion of asymmetric cell division; these neuronal abnormalities appear to be due to reduced Cenpj protein expression level.
Sas4-/- mutants lack primary cilia and therefore cannot respond to Hedgehog signals but other developmental signaling pathways are normal in the mutants.
we have developed a mouse (Cenpj(tm/tm)) that recapitulates many of the clinical features of Seckel syndrome thus providing clear confirmation that specific mutations of CENPJ can cause Seckel syndrome.
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