Q56974 · SCTC_YERPE

  • Protein
    Type 3 secretion system secretin
  • Gene
    sctC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell outer membrane
Cellular Componenttype II protein secretion system complex
Cellular Componenttype III protein secretion system complex
Biological Processprotein secretion
Biological Processprotein secretion by the type III secretion system

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Type 3 secretion system secretin
  • Short names
    T3SS secretin
  • Alternative names
    • Type III secretion protein YscC

Gene names

    • Name
      sctC
    • Synonyms
      yscC
    • Ordered locus names
      YPCD1.52

Encoded on

  • Plasmid pCD1

Organism names

  • Taxonomic identifier
  • Strains
    • KIM5 / Biovar Mediaevalis
    • C790
    • CO-92 / Biovar Orientalis
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    Q56974
  • Secondary accessions
    • A0A0H2W163
    • Q74YX8
    • Q7BTX6

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_501410547627-607Type 3 secretion system secretin

Proteomic databases

Expression

Induction

Thermally induced and down-regulated in the presence of calcium.

Interaction

Subunit

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex (By similarity).
Interacts with the inner membrane ring inner protein YscD/SctD (PubMed:21357482).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q56974yscD Q569752EBI-2861069, EBI-6413916

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the bacterial secretin family. T3SS SctC subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    607
  • Mass (Da)
    67,345
  • Last updated
    1996-11-01 v1
  • Checksum
    A8DA2AF1EFDB0883
MAFPLHSFFKRVLTGTLLLLSNYSWAQELDWLPIPYVYVAKGESLRDLLIDFSANYDATVVVSDKINDKVSGQFEHDNPQDFLQHIASLYNLVWYYDGNVLYIFKNSEVASRLIRLQESEAAELKLALQRSGIWEPRFGWRPDASNRLVYVSGPPRYLELVEQTAAALEQQTQIRSEKTGALAIEIFPLKYASASDRTIHYRDDEVAAPGVATILQRVLSDATIQQVTVDNQRIPQAATRASAQAKVEADPSLNAIIVRDSPERMPMYQRLIHALDKPSARIEVALSIVDINADQLTELGVDWRVGIRTGNNHQVVIKTTGDQSNIASNGALGSLIDARGLDYLLARVNLLENEGSAQVVSRPTLLTQENAQAVIDHHETYYVKVTGKEVAELKGITYGTMLRMTPRVLTQGDKSEISLNLHIEDGNQKPNSSGIDGIPTISRTVVDTVARVGHGQSLIIGGIYRDELSVALSKVPLLGDIPYLGALFRRKSELTRRTVRLFIIEPRIIDEGIAHHLALGNGRDLRTGILAVDEISNQSTTLNKLLGGFQCQPLNKAQEVQKWLSQNNKSSYLTQCKMDKSLGWRVVEGACTPAESWCVSAPKRGVL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M83225
EMBL· GenBank· DDBJ
AAA27638.1
EMBL· GenBank· DDBJ
Genomic DNA
AF074612
EMBL· GenBank· DDBJ
AAC69781.1
EMBL· GenBank· DDBJ
Genomic DNA
AF053946
EMBL· GenBank· DDBJ
AAC62552.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ612242
EMBL· GenBank· DDBJ
ADV16646.1
EMBL· GenBank· DDBJ
Genomic DNA
AL117189
EMBL· GenBank· DDBJ
CAB54929.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp