Q55G49 · Q55G49_DICDI
- Protein18S rRNA aminocarboxypropyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids365 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Catalytic activity
- an N1-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 79 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 127 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 150 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 18S rRNA aminocarboxypropyltransferase activity | |
Molecular Function | S-adenosyl-L-methionine binding | |
Biological Process | enzyme-directed rRNA pseudouridine synthesis | |
Biological Process | maturation of SSU-rRNA |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name18S rRNA aminocarboxypropyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ55G49
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-31 | Disordered | |||
Domain | 64-96 | RNase L inhibitor RLI-like possible metal-binding | |||
Domain | 101-227 | 16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal | |||
Region | 254-365 | Disordered | |||
Compositional bias | 262-333 | Acidic residues | |||
Compositional bias | 334-359 | Basic and acidic residues | |||
Sequence similarities
Belongs to the TDD superfamily. TSR3 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)41,805
- Last updated2005-05-24 v1
- Checksum566A976530006450
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 262-333 | Acidic residues | |||
Compositional bias | 334-359 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000003 EMBL· GenBank· DDBJ | EAL73364.1 EMBL· GenBank· DDBJ | Genomic DNA |