Q55FQ9 · LMPC_DICDI
- ProteinLysosome membrane protein 2-C
- GenelmpC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids782 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May act as a lysosomal receptor (By similarity).
May be involved role in macropinocytosis and fluid phase exocytosis
May be involved role in macropinocytosis and fluid phase exocytosis
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic vesicle membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | lysosome | |
Cellular Component | phagocytic vesicle | |
Cellular Component | phagolysosome | |
Cellular Component | vesicle membrane | |
Molecular Function | scavenger receptor activity | |
Biological Process | phagocytosis, engulfment |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysosome membrane protein 2-C
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ55FQ9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Multi-pass membrane protein
Note: Localizes to membranes of endolysosomal vesicles and macropinosomes.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-7 | Cytoplasmic | ||||
Sequence: MVANNKG | ||||||
Transmembrane | 8-28 | Helical | ||||
Sequence: LLIAGLLLSVIGAALFVISLA | ||||||
Topological domain | 29-739 | Lumenal | ||||
Sequence: LLPSVLNVATNNAIVDAVIVDSFKSQRYNDWAGQKSVDNYFKQYYYLWNLTNPNEVLNGKNCNFEKIGPFNYKYEWNNSKVSFSDDGNLINYIQSKSYKWIEGEDSLNPFTVSTTNFNPAYLGLLSTLSKNSITLGMTAEDLLYTLASAPQTKQFLEYLSSDNFTMIAYFYNGPKYFNQQYQLLLSTINNNLTTTPTIYFLEQWSNSTIIPTNGNSSLWDNMLISYGLDSPSGISLQSALEILNPMNQYSLLNSTNGISYWINAVFNGPNSNSYQILEQELGINQAQLTLVMIWWLKGFNDQYTMSQLLKQCEIESIELLGVCQFITTIPLGYKSISQFNITNLPWLEPIEIPIAMGTNLTISTNEAQSNLFNDSIDDSLLTIHGLGLFLEQMSTNSNNFTKWNLTNNDAMTMIGYFLSYIPNTTGYSIKSVQSFYNTSGLIVTRTANEWLWDCQDDLLDYLGIDQQCSFQQNNTIFKPSTVYTGKKDLSLTNQYQQFQEQSTLTIWNGTVNVTGFVENGQMAPLVQDNLPQSLTIFEENILRPLSLVHSSSSSVMGVSTQRYYLPNQSFPIDPVFNNSINGFANLTGLFNGVPIYVSLWDMYGVPIEYSSLYINGLNQTYENAEIPLDLEPITGNTLYYNLKLQINLQIPSNANSLWFSSLGNWTNIFSPTNSNSFGIFYPSLKIGQTATASTNDINLLKQQFKQIQTVK | ||||||
Transmembrane | 740-760 | Helical | ||||
Sequence: IAPVVVVSIFGGILLIAGLVM | ||||||
Topological domain | 761-782 | Cytoplasmic | ||||
Sequence: AINGFRKTFYNNNQYNGYNIIN |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000327759 | 1-782 | Lysosome membrane protein 2-C | |||
Sequence: MVANNKGLLIAGLLLSVIGAALFVISLALLPSVLNVATNNAIVDAVIVDSFKSQRYNDWAGQKSVDNYFKQYYYLWNLTNPNEVLNGKNCNFEKIGPFNYKYEWNNSKVSFSDDGNLINYIQSKSYKWIEGEDSLNPFTVSTTNFNPAYLGLLSTLSKNSITLGMTAEDLLYTLASAPQTKQFLEYLSSDNFTMIAYFYNGPKYFNQQYQLLLSTINNNLTTTPTIYFLEQWSNSTIIPTNGNSSLWDNMLISYGLDSPSGISLQSALEILNPMNQYSLLNSTNGISYWINAVFNGPNSNSYQILEQELGINQAQLTLVMIWWLKGFNDQYTMSQLLKQCEIESIELLGVCQFITTIPLGYKSISQFNITNLPWLEPIEIPIAMGTNLTISTNEAQSNLFNDSIDDSLLTIHGLGLFLEQMSTNSNNFTKWNLTNNDAMTMIGYFLSYIPNTTGYSIKSVQSFYNTSGLIVTRTANEWLWDCQDDLLDYLGIDQQCSFQQNNTIFKPSTVYTGKKDLSLTNQYQQFQEQSTLTIWNGTVNVTGFVENGQMAPLVQDNLPQSLTIFEENILRPLSLVHSSSSSVMGVSTQRYYLPNQSFPIDPVFNNSINGFANLTGLFNGVPIYVSLWDMYGVPIEYSSLYINGLNQTYENAEIPLDLEPITGNTLYYNLKLQINLQIPSNANSLWFSSLGNWTNIFSPTNSNSFGIFYPSLKIGQTATASTNDINLLKQQFKQIQTVKIAPVVVVSIFGGILLIAGLVMAINGFRKTFYNNNQYNGYNIIN | ||||||
Glycosylation | 77 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 105 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 191 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 219 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 234 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 243 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 281 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 368 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 387 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 401 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 427 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 432 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 451 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 465 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 501 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 536 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 540 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 595 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 605 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 613 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 646 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 692 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Heavily glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Found at all stages of development in comparable quantities (at protein level).
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 777-781 | Tyrosine-type lysosomal sorting signal | ||||
Sequence: GYNII |
Sequence similarities
Belongs to the CD36 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length782
- Mass (Da)87,876
- Last updated2005-05-24 v1
- Checksum5FA958647B487976
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 5 | in Ref. 1; AAK30041 | ||||
Sequence: N → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF238325 EMBL· GenBank· DDBJ | AAK30041.1 EMBL· GenBank· DDBJ | mRNA | ||
AAFI02000003 EMBL· GenBank· DDBJ | EAL73172.1 EMBL· GenBank· DDBJ | Genomic DNA |