Q55CT1 · NCPR_DICDI

Function

function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per monomer.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164-173FMN (UniProtKB | ChEBI)
Binding site199FMN (UniProtKB | ChEBI)
Binding site297NADP+ (UniProtKB | ChEBI)
Binding site468-470FAD (UniProtKB | ChEBI)
Binding site484-487FAD (UniProtKB | ChEBI)
Binding site527NADP+ (UniProtKB | ChEBI)
Binding site586-587NADP+ (UniProtKB | ChEBI)
Binding site592-596NADP+ (UniProtKB | ChEBI)
Binding site666FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Molecular Functionoxidoreductase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH--cytochrome P450 reductase
  • EC number
  • Short names
    CPR
    ; P450R
  • Alternative names
    • NADPH oxidoreductase B

Gene names

    • Name
      redB
    • ORF names
      DDB_G0269912

Organism names

Accessions

  • Primary accession
    Q55CT1

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-8Lumenal
Transmembrane9-29Helical
Topological domain30-667Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003512231-667NADPH--cytochrome P450 reductase

Proteomic databases

Expression

Developmental stage

Present during growth and development.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain72-215Flavodoxin-like
Domain277-511FAD-binding FR-type

Sequence similarities

Belongs to the NADPH--cytochrome P450 reductase family.
In the N-terminal section; belongs to the flavodoxin family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    667
  • Mass (Da)
    76,193
  • Last updated
    2005-05-24 v1
  • MD5 Checksum
    F3BED16DF7877725DE8ADFA03A62AC49
MEILESIDFIEVLILDNLGAIIIVAVIVGTYLYMNKPPPPPPVFNKPNNKINKEAQKPKKTITKNEDGKKVMKIFFGTQTRTAEDFSRIIEKECKKIGIPCEVVDLESYEHEQELHSESFVMFLVATHGEGDPTDNAKEFYLWLTNDERPTDLLNGVPFTVFGLGNKTYEHYNAVARVIDRRMEELGGKRVFERGEGDDDATLEEDFNRWKKDMWPVVCKFLGYELKSTEDDKFVPRFRMVTLNQDSKDINDPFIKIVSTPLKPKLSTDNKVIYDMKNPYYAEVLENRELHSNESDRSCRHIEFKLGDEVSYTTGDHLGVFPINDSKLVEQLIKRLGVNGDDMIALVPIDQEGSVIKASFGPMTIRRAFSEHLDITNPVRKSVLRALAESTTNEEEKKRLLYLATEEANEEYNKYIKNDFRGVVDLLESFPGLQPLIAHFLEFTPRLPARMYSISSSPHNKNGVVSITSVVVNFTTGNQRAHNGVASTWLSHLKVGDKVPLFVRESHFKLPSAATEQKPVIMVGPGTGLAPFRGFLQELQHRNHSQQQQSLLFFGCRSDTVDYIYREELEQYHQSSVLGDLVVAFSRKTSQKVYVQNKLLEHKEKVWELLNKGAYFYVCGDGRNMSKAVQQALLSIIKEFGSKDDNSAQQFIDDMSSHGRYLQDVWF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000005
EMBL· GenBank· DDBJ
EAL72306.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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