Q550Q4 · RHEB_DICDI
- ProteinGTP-binding protein Rheb homolog
- Generheb
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids185 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Binds GTP and exhibits intrinsic GTPase activity.
Catalytic activity
- GTP + H2O = GDP + phosphate + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 18 | GTP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 19 | GTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 20 | GTP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 20 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 21 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 35 | GTP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 38 | GTP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 38 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 119 | GTP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 122 | GTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 150 | GTP (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | autophagosome | |
Cellular Component | cytoplasmic vesicle | |
Cellular Component | plasma membrane | |
Molecular Function | GDP binding | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | metal ion binding | |
Biological Process | negative regulation of phagocytosis | |
Biological Process | positive regulation of TOR signaling | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGTP-binding protein Rheb homolog
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ550Q4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000327698 | 1-182 | GTP-binding protein Rheb homolog | |||
Sequence: MAPQKHRKICVMGSRAVGKSTITMQFVESHCPDSYHPTIENTYQKIIRHQGQEYSVEIIDTAGQDEYSILQKQYSIGIHGYILVYSVTSVSSLEVIKVLNDKILSSLGAEKIPRVLVGNKSDLDNERNISRDQGIQLANEWECAFVECSGKNNENVEEVFKQILNEVNKGSTGPEPPQKEGC | ||||||
Modified residue | 182 | Cysteine methyl ester | ||||
Sequence: C | ||||||
Lipidation | 182 | S-farnesyl cysteine | ||||
Sequence: C | ||||||
Propeptide | PRO_0000327699 | 183-185 | Removed in mature form | |||
Sequence: ILM |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 35-43 | Effector region | ||||
Sequence: YHPTIENTY |
Sequence similarities
Belongs to the small GTPase superfamily. Rheb family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length185
- Mass (Da)20,715
- Last updated2005-05-24 v1
- Checksum586ADA3B17BCC990
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000019 EMBL· GenBank· DDBJ | EAL69022.1 EMBL· GenBank· DDBJ | Genomic DNA |