Q54T86 · DWWA_DICDI

Function

function

Involved in regulation of actin cytoskeleton organization and cytokinesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular Functioncalmodulin binding
Molecular Functionkinase binding
Molecular Functionmolecular adaptor activity
Biological Processactin filament organization
Biological Processcell migration
Biological Processmitotic cytokinesis
Biological Processnegative regulation of organ growth
Biological Processregulation of DNA-templated transcription
Biological Processregulation of hippo signaling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    WW domain-containing protein A

Gene names

    • Name
      dwwA
    • ORF names
      DDB_G0281827

Organism names

Accessions

  • Primary accession
    Q54T86
  • Secondary accessions
    • Q86SB0

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Nucleus, nucleolus
Note: In living cells localizes to the cell cortex and nucleus. In formaldehyde fixed cells localizes to the nucleolus.

Keywords

Phenotypes & Variants

Disruption phenotype

Cells fail to complete the final step of cytokinesis and form multinucleated cells when grown on a solid surface. Null mutants show excessive accumulation of F-actin around the periphery of the ventral surface. When grown in suspension, mutants lacking dwwA complete cytokinesis normally. Mutants lacking the N-terminal C2 domain fail to localize to the cell cortex.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002936281-568WW domain-containing protein A

Proteomic databases

Expression

Developmental stage

Expressed during vegetative growth. Expression decreases rapidly during early development and is not detected after 12 hours of development.

Interaction

Subunit

Interacts with calmodulin in the absence of Ca2+.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain6-129C2
Domain325-359WW 1
Compositional bias376-417Polar residues
Region376-461Disordered
Compositional bias434-457Basic and acidic residues
Domain519-552WW 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    568
  • Mass (Da)
    64,751
  • Last updated
    2005-05-24 v1
  • Checksum
    F297EBB82BD15C78
MSNKNPLNNSNGSNSSTIVNSDKFLVKIHSLSVSHTSKSSNIYLVGDFDQFKQFKTETKKSSSTHGSCIYNEFAMEFQYETKYIHKLDHKHFKICVYKKKSIGSDKYIGSFGVDLYTLATGPISHDVVFQKDNTGVGRLQFRLEMNHITDIQISFKSILLSNLMKQSNYQIDYSLNKINPLKSSIIENTICPSWYNQSSILMNISLKDLVDGSIFFNLKDTKSSKVIGELKLPVKSIFSFVEGDIKIVKTLLYNEKQNKICDACIEIQFNNIPQLAQLRGGIQTEQGIRGAESFFSGVPLPKIIGEISNASTSDGYSKEAQLQHVKLPDGWESRIDPVSGKVFYLNHNNKTTSWISPLEHAPVKKRTPTVVISNTTILDNNNNNNNNNNNNNNNNNNNNNNINNTNNIQQKQQAQQQPVQPPPQPVQQQVQQPQQKEKEKEKEINAEDYKISRPKKTPATPEEAAVIIQRTFRNHKKQSYNKTIRNSKTIIPPNNVQQQQPQQTEKPSIYQVFGQQIDQGLPNGWEVRQDQFGRVFYVDHINRATTWTRPTVKHPKQHQQATLVQQRK

Features

Showing features for sequence conflict, compositional bias.

Type
IDPosition(s)Description
Sequence conflict209in Ref. 1; BAC56858
Compositional bias376-417Polar residues
Compositional bias434-457Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB089315
EMBL· GenBank· DDBJ
BAC56858.1
EMBL· GenBank· DDBJ
mRNA
AAFI02000043
EMBL· GenBank· DDBJ
EAL66473.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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