Q54RD6 · PP2AB_DICDI
- ProteinProtein phosphatase 2A catalytic subunit B
- Genepho2B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids312 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay (PubMed:20493808).
The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).
The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway (PubMed:20493808).
Catalytic activity
- O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
Cofactor
Note: Binds 2 manganese ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55 | Mn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 57 | Mn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 83 | Mn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 83 | Mn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 115 | Mn2+ 2 (UniProtKB | ChEBI) | |||
Active site | 116 | Proton donor | |||
Binding site | 165 | Mn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 240 | Mn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | FAR/SIN/STRIPAK complex | |
Cellular Component | plasma membrane | |
Cellular Component | Ras guanyl-nucleotide exchange factor complex | |
Molecular Function | metal ion binding | |
Molecular Function | myosin phosphatase activity | |
Molecular Function | protein serine/threonine phosphatase activity | |
Biological Process | asymmetric protein localization to old mitotic spindle pole body |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein phosphatase 2A catalytic subunit B
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54RD6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells (PubMed:20493808).
Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808).
Membrane localization of the Sca1 complex is regulated by scaA phosphorylation by PKB and PKB-related PKBR1 (PubMed:20493808).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000368207 | 1-312 | Protein phosphatase 2A catalytic subunit B | ||
Keywords
- PTM
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)35,694
- Last updated2005-05-24 v1
- Checksum11DA221AB338021F
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000051 EMBL· GenBank· DDBJ | EAL65832.1 EMBL· GenBank· DDBJ | Genomic DNA |