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Q54NG5 · Q54NG5_DICDI

Function

function

Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentmembrane
Molecular Functionhydrolase activity
Molecular Functionlipoprotein particle receptor binding
Molecular Functionmetal ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Reelin

Gene names

    • ORF names
      DDB_G0285271

Organism names

Accessions

  • Primary accession
    Q54NG5

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane949-968Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-23
ChainPRO_500424922424-1037Reelin
Disulfide bond661↔671
Disulfide bond679↔688

Keywords

Proteomic databases

Interaction

Subunit

Oligomer of disulfide-linked homodimers.

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region161-181Disordered
Domain657-689EGF-like

Sequence similarities

Belongs to the reelin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,037
  • Mass (Da)
    117,484
  • Last updated
    2005-05-24 v1
  • MD5 Checksum
    3F142B605789824B2B53514A22D8E8EC
MEKNHVFQLIFYSILILIVNVNSNKIEYSSYSEDDKSINITLITNIQDLEISYYYNPIQHLSIIKSIEPIPIIRNNIPFKCGYLLDNKGYQINLINLKDDFGTNDFYNNIICNATSNKITENSIQLKGNDINTTYEFICIDDNDNINNNDNIDNIDNLNNYKNNNNNNSSSNNNSNRNNNNIDNIDNIDNLIINSSDYHGDSNNSNNSNNNNSNEIDKFFCLKNDLSNHTLCTYNSKYACLQSIIFNVTRIKRGFSINKNFISSNPLIKRSNIISINGFYKSIYLERKEKKIVGEIKSLNGIVTLSGIPFFREKLSNYSFIMGDNILPISEYFENDFQYREDDNVLISMETNQTILNLTRYSDNILKVQLEGIEIKEFEIDTQNKMILSIEELNDTKQYIQINCEGCIGAQLRGLTMDIGQTVNSTSFKLYYDTFTLYSPLYLQSPIAPFETSNLVIVKPIYDYPIKGEVLQLKSKRYKNPIITVSGYYLPSNYGFFLFTPEFLIPGGAIIRSYIIKSTNIGSYWQHSIELPVNQGSGEFRLYKNNFIIIDGKVNIINKTVEIFPFKFDEKPIVENGAGYLTISGQSFNYYLPVLTIEEETSWICGNISIFPDIDQLICKVNKHPIQDRFYNVVLKKIISYRSSYNSEPFLMNYLPSGWKCPNNCSGNGHCDGSLNCICDEGFSGYDCSILINQVLTNANSLPISTNQQRLGSFSMTGNHLNNMNFQISLVGIITDSDTNLEAAETSFKYSTKNSNSVYYKDSVNGFTLDAKNSNYSISATAQFNPNVYLNNSINYNGIYLDKLSNNSVYLKVNLTIGELNNKDILKVIYKVNLNVNNQILGDLKKSVTISSPINNKILIKHLDSCSCLQIHLSNRFINNGSINDGYASLVKMESITEQDNSIYFSIEIPINNNNINSTSGVSLEVTSSFSVFNEIIVFEILGTDGNSLIIFGIVVSLVLLFYLMFGFKRNLTNGILNGKTNSFELLPMNGDDLGAPDDDCFPEKGYIFNPNDINDSTLSDILVNEFIESKATCETD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000077
EMBL· GenBank· DDBJ
EAL64799.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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