Q54N80 · FKBP3_DICDI
- ProteinFK506-binding protein 3
- Genefkbp3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids194 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity
- [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
Activity regulation
Inhibited by both FK506 and rapamycin.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | peptidyl-prolyl cis-trans isomerase activity | |
Biological Process | asexual reproduction | |
Biological Process | chaperone-mediated protein folding | |
Biological Process | protein peptidyl-prolyl isomerization |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFK506-binding protein 3
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54N80
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 148-168 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_0000331282 | 20-194 | FK506-binding protein 3 | ||
Proteomic databases
Expression
Developmental stage
Highly expressed in growing cells. Expression levels decrease during the first few hours of development.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 44-133 | PPIase FKBP-type | |||
Region | 173-194 | Disordered | |||
Sequence similarities
Belongs to the FKBP-type PPIase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length194
- Mass (Da)21,190
- Last updated2005-05-24 v1
- MD5 Checksum73481861287C2415ECDA00A8F567753A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000079 EMBL· GenBank· DDBJ | EAL64565.1 EMBL· GenBank· DDBJ | Genomic DNA |