Q54N80 · FKBP3_DICDI

Function

function

PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Activity regulation

Inhibited by both FK506 and rapamycin.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionpeptidyl-prolyl cis-trans isomerase activity
Biological Processasexual reproduction
Biological Processchaperone-mediated protein folding
Biological Processprotein peptidyl-prolyl isomerization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    FK506-binding protein 3
  • EC number
  • Alternative names
    • Peptidyl-prolyl cis-trans isomerase (PPIase)
    • Rotamase

Gene names

    • Name
      fkbp3
    • Synonyms
      impA
    • ORF names
      DDB_G0285455

Organism names

Accessions

  • Primary accession
    Q54N80

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane148-168Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_000033128220-194FK506-binding protein 3

Proteomic databases

Expression

Developmental stage

Highly expressed in growing cells. Expression levels decrease during the first few hours of development.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain44-133PPIase FKBP-type
Region173-194Disordered

Sequence similarities

Belongs to the FKBP-type PPIase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    194
  • Mass (Da)
    21,190
  • Last updated
    2005-05-24 v1
  • MD5 Checksum
    73481861287C2415ECDA00A8F567753A
MNKFLIALLVLATLAVSFSQEIGVSILKTDTPKGECKGKTASIGDYISLKYVGKFEDGTVFDSSEIHGGFSFNFTIGERKVIPGLEIGTINICEGEKRSIKIPYQLAYGENGIENAIPPRTDIYFDLEVVSIEGAPAQPFYYQLIPSVGTIIAFSMLAGFIVLVKFIIKRYPDESNSKKPAPGKPKKTKAAKQN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000079
EMBL· GenBank· DDBJ
EAL64565.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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