Q54N08 · ALKB_DICDI
- ProteinAlpha-ketoglutarate-dependent dioxygenase alkB
- GenealkB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids393 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
Cofactor
Note: Binds 1 Fe2+ ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 217 | substrate | |||
Binding site | 224-226 | substrate | |||
Binding site | 267-269 | 2-oxoglutarate (UniProtKB | ChEBI) | |||
Binding site | 278 | Fe cation (UniProtKB | ChEBI); catalytic | |||
Binding site | 280 | Fe cation (UniProtKB | ChEBI); catalytic | |||
Binding site | 308 | substrate | |||
Binding site | 334 | Fe cation (UniProtKB | ChEBI); catalytic | |||
Binding site | 370-376 | 2-oxoglutarate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | broad specificity oxidative DNA demethylase activity | |
Molecular Function | ferrous iron binding | |
Molecular Function | oxidative RNA demethylase activity | |
Biological Process | DNA repair | |
Biological Process | oxidative RNA demethylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-ketoglutarate-dependent dioxygenase alkB
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54N08
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000384446 | 1-393 | Alpha-ketoglutarate-dependent dioxygenase alkB | ||
Proteomic databases
Expression
Induction
Up-regulated by phagocytic stimuli.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-30 | Disordered | |||
Compositional bias | 181-197 | Basic and acidic residues | |||
Region | 181-203 | Disordered | |||
Sequence similarities
Belongs to the alkB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length393
- Mass (Da)45,446
- Last updated2005-05-24 v1
- MD5 Checksum9CDD9537B5A417A218B784B9BDFDB0A0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 181-197 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000079 EMBL· GenBank· DDBJ | EAL64625.1 EMBL· GenBank· DDBJ | Genomic DNA |