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Q54N08 · ALKB_DICDI

Function

function

Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )
Note: Binds 1 Fe2+ ion per subunit.

Features

Showing features for binding site.

139350100150200250300350
TypeIDPosition(s)Description
Binding site217substrate
Binding site224-226substrate
Binding site267-2692-oxoglutarate (UniProtKB | ChEBI)
Binding site278Fe cation (UniProtKB | ChEBI); catalytic
Binding site280Fe cation (UniProtKB | ChEBI); catalytic
Binding site308substrate
Binding site334Fe cation (UniProtKB | ChEBI); catalytic
Binding site370-3762-oxoglutarate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionbroad specificity oxidative DNA demethylase activity
Molecular Functionferrous iron binding
Molecular Functionoxidative RNA demethylase activity
Biological ProcessDNA repair
Biological Processoxidative RNA demethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-ketoglutarate-dependent dioxygenase alkB
  • EC number
  • Alternative names
    • Alkylated DNA repair protein alkB

Gene names

    • Name
      alkB
    • ORF names
      DDB_G0285575

Organism names

Accessions

  • Primary accession
    Q54N08

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003844461-393Alpha-ketoglutarate-dependent dioxygenase alkB

Proteomic databases

Expression

Induction

Up-regulated by phagocytic stimuli.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-30Disordered
Compositional bias181-197Basic and acidic residues
Region181-203Disordered

Sequence similarities

Belongs to the alkB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    393
  • Mass (Da)
    45,446
  • Last updated
    2005-05-24 v1
  • MD5 Checksum
    9CDD9537B5A417A218B784B9BDFDB0A0
MYETEEDPTTSNVATTNNEKTASTAATTTEPVKKVTEFMRVQRLFRQVTKSANGKNIPKEKREPIDYSPVLDFHNLENNTEENKKLIIDCTSNVTTHDFEFNRDTEFYLHPREWKVYGLQGYPGFYFIKSPFTASQQKKWIKHALEDYADPPNNNNITLFHGPIKNLWKNGEKELINEELKSQGKHDDDEIEQPTRPLDKNGEPLPTYRQLLDKLAWSTLGYQYQWTPRLYSEEFYEEFPDDLQELVQKIAIATKFDPYVAEAATVNFYSEDSIMGGHLDDAEQEMEKPIISISFGSTAVFLMGAETRDIAPVPLFIRSGDIVIMGGRSRYCYHGVAKIVENSFDLGLIDENDDQDLKYKIQWLKEKNRRVNINTRQVFKVPKLGGKLINKNE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias181-197Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000079
EMBL· GenBank· DDBJ
EAL64625.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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