Q54KM6 · KAT_DICDI
- ProteinKynurenine--oxoglutarate transaminase
- Geneccbl
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids435 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity).
Catalytic activity
- L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O
Cofactor
Pathway
Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | substrate | |||
Binding site | 198 | substrate | |||
Binding site | 413 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | mitochondrion | |
Molecular Function | cysteine-S-conjugate beta-lyase activity | |
Molecular Function | glutamine-phenylpyruvate transaminase activity | |
Molecular Function | kynurenine-oxoglutarate transaminase activity | |
Molecular Function | pyridoxal phosphate binding | |
Molecular Function | transaminase activity | |
Biological Process | biosynthetic process | |
Biological Process | L-kynurenine catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKynurenine--oxoglutarate transaminase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54KM6
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000327725 | 1-435 | Kynurenine--oxoglutarate transaminase | ||
Modified residue | 262 | N6-(pyridoxal phosphate)lysine | |||
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length435
- Mass (Da)48,553
- Last updated2005-05-24 v1
- MD5 Checksum1EDB932353353DA16BD051313FE908DE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000099 EMBL· GenBank· DDBJ | EAL63836.1 EMBL· GenBank· DDBJ | Genomic DNA |