Q54I48 · CTL2_DICDI

Function

function

Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentmitochondrial outer membrane
Cellular Componentplasma membrane
Molecular Functionantiporter activity
Molecular Functioncholine transmembrane transporter activity
Molecular Functionethanolamine transmembrane transporter activity
Molecular Functiontransmembrane transporter activity
Biological Processcholine transport
Biological Processethanolamine transport
Biological Processtransmembrane transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Choline transporter-like protein 2
  • Alternative names
    • Solute carrier family 44 member 2

Gene names

    • Name
      slc44a2
    • Synonyms
      ctl2
    • ORF names
      DDB_G0289013

Organism names

Accessions

  • Primary accession
    Q54I48

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Mitochondrion outer membrane
; Multi-pass membrane protein
Note: Mainly expressed in mitochondria.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-31Cytoplasmic
Transmembrane32-52Helical
Topological domain53-204Extracellular
Transmembrane205-225Helical
Topological domain226Cytoplasmic
Transmembrane227-247Helical
Topological domain248-282Extracellular
Transmembrane283-303Helical
Topological domain304-319Cytoplasmic
Transmembrane320-340Helical
Topological domain341-381Extracellular
Transmembrane382-402Helical
Topological domain403-432Cytoplasmic
Transmembrane433-453Helical
Topological domain454-530Extracellular
Transmembrane531-551Helical
Topological domain552-559Cytoplasmic
Transmembrane560-580Helical
Topological domain581-628Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00003279351-628Choline transporter-like protein 2
Glycosylation82N-linked (GlcNAc...) asparagine
Glycosylation118N-linked (GlcNAc...) asparagine
Glycosylation146N-linked (GlcNAc...) asparagine
Glycosylation168N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    628
  • Mass (Da)
    71,809
  • Last updated
    2005-05-24 v1
  • Checksum
    B095D3138E9305A6
MSSEDLQDHHEIGNEVIKKKGVYTKKKCQDCFFLILFLLFWAGMIVVAAFGVKNGKPDRIVKGTDQYGNICGVNNIEQGILNETQARDTTNEPYVYFIYYPDLIGINYRVICIEECPNSTYTDLNDPNQLICDYGTVPATNQISPNGTCMGKIKSKLIFNRCIPDVTNTSVVLNSIVDEIYQFVNNQLTSDLSVEILTDLTNSWRYLIYGALIAMGLGLTWIFLLRFFAGFITWLTVFAAYACLGLLTAQVYFQWQDSKDAYENTIPSQRLVMQEKNILALKVIFIILCVVCGIFALILLALFSRIRIAIRIIKECSRAIGIMPSIFFFPIFIFLLLCGFTVYWVYIGVYLATAGSPTYDDQYRFTGYEADSKLQKIQIYHFFGYLWTFAFILALNQTTIAGAISSWYWVQDKKDTPFFPVWSSFFRVIRYHLGSIALGSLILAIVQFIRWVLRFLEKKFKGKEAYLARFIVRCLNCIFGCFERFIKFLDKNAYIMVSIYGYSFCQGAKRGFQLVLTNILRVAAVNLVSSFLMFLGRVFITAATVGISLYLLKEHENLSFYIIPVILIGFIAFAISTGFMSVYDMSIDTMLLCFCEDCERNDGSPERPYYMSKSLRKFVDGKGRSKCC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000129
EMBL· GenBank· DDBJ
EAL62922.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp