Q54I48 · CTL2_DICDI
- ProteinCholine transporter-like protein 2
- Geneslc44a2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids628 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Choline/H+ antiporter, mainly in mitochodria. Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway.
Catalytic activity
- choline(out) + n H+(in) = choline(in) + n H+(out)
- ethanolamine(out) + n H+(in) = ethanolamine(in) + n H+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | choline transmembrane transporter activity | |
Molecular Function | ethanolamine transmembrane transporter activity | |
Molecular Function | transmembrane transporter activity | |
Biological Process | choline transport | |
Biological Process | ethanolamine transport | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCholine transporter-like protein 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54I48
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Note: Mainly expressed in mitochondria.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Cytoplasmic | ||||
Sequence: MSSEDLQDHHEIGNEVIKKKGVYTKKKCQDC | ||||||
Transmembrane | 32-52 | Helical | ||||
Sequence: FFLILFLLFWAGMIVVAAFGV | ||||||
Topological domain | 53-204 | Extracellular | ||||
Sequence: KNGKPDRIVKGTDQYGNICGVNNIEQGILNETQARDTTNEPYVYFIYYPDLIGINYRVICIEECPNSTYTDLNDPNQLICDYGTVPATNQISPNGTCMGKIKSKLIFNRCIPDVTNTSVVLNSIVDEIYQFVNNQLTSDLSVEILTDLTNSW | ||||||
Transmembrane | 205-225 | Helical | ||||
Sequence: RYLIYGALIAMGLGLTWIFLL | ||||||
Topological domain | 226 | Cytoplasmic | ||||
Sequence: R | ||||||
Transmembrane | 227-247 | Helical | ||||
Sequence: FFAGFITWLTVFAAYACLGLL | ||||||
Topological domain | 248-282 | Extracellular | ||||
Sequence: TAQVYFQWQDSKDAYENTIPSQRLVMQEKNILALK | ||||||
Transmembrane | 283-303 | Helical | ||||
Sequence: VIFIILCVVCGIFALILLALF | ||||||
Topological domain | 304-319 | Cytoplasmic | ||||
Sequence: SRIRIAIRIIKECSRA | ||||||
Transmembrane | 320-340 | Helical | ||||
Sequence: IGIMPSIFFFPIFIFLLLCGF | ||||||
Topological domain | 341-381 | Extracellular | ||||
Sequence: TVYWVYIGVYLATAGSPTYDDQYRFTGYEADSKLQKIQIYH | ||||||
Transmembrane | 382-402 | Helical | ||||
Sequence: FFGYLWTFAFILALNQTTIAG | ||||||
Topological domain | 403-432 | Cytoplasmic | ||||
Sequence: AISSWYWVQDKKDTPFFPVWSSFFRVIRYH | ||||||
Transmembrane | 433-453 | Helical | ||||
Sequence: LGSIALGSLILAIVQFIRWVL | ||||||
Topological domain | 454-530 | Extracellular | ||||
Sequence: RFLEKKFKGKEAYLARFIVRCLNCIFGCFERFIKFLDKNAYIMVSIYGYSFCQGAKRGFQLVLTNILRVAAVNLVSS | ||||||
Transmembrane | 531-551 | Helical | ||||
Sequence: FLMFLGRVFITAATVGISLYL | ||||||
Topological domain | 552-559 | Cytoplasmic | ||||
Sequence: LKEHENLS | ||||||
Transmembrane | 560-580 | Helical | ||||
Sequence: FYIIPVILIGFIAFAISTGFM | ||||||
Topological domain | 581-628 | Extracellular | ||||
Sequence: SVYDMSIDTMLLCFCEDCERNDGSPERPYYMSKSLRKFVDGKGRSKCC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000327935 | 1-628 | Choline transporter-like protein 2 | |||
Sequence: MSSEDLQDHHEIGNEVIKKKGVYTKKKCQDCFFLILFLLFWAGMIVVAAFGVKNGKPDRIVKGTDQYGNICGVNNIEQGILNETQARDTTNEPYVYFIYYPDLIGINYRVICIEECPNSTYTDLNDPNQLICDYGTVPATNQISPNGTCMGKIKSKLIFNRCIPDVTNTSVVLNSIVDEIYQFVNNQLTSDLSVEILTDLTNSWRYLIYGALIAMGLGLTWIFLLRFFAGFITWLTVFAAYACLGLLTAQVYFQWQDSKDAYENTIPSQRLVMQEKNILALKVIFIILCVVCGIFALILLALFSRIRIAIRIIKECSRAIGIMPSIFFFPIFIFLLLCGFTVYWVYIGVYLATAGSPTYDDQYRFTGYEADSKLQKIQIYHFFGYLWTFAFILALNQTTIAGAISSWYWVQDKKDTPFFPVWSSFFRVIRYHLGSIALGSLILAIVQFIRWVLRFLEKKFKGKEAYLARFIVRCLNCIFGCFERFIKFLDKNAYIMVSIYGYSFCQGAKRGFQLVLTNILRVAAVNLVSSFLMFLGRVFITAATVGISLYLLKEHENLSFYIIPVILIGFIAFAISTGFMSVYDMSIDTMLLCFCEDCERNDGSPERPYYMSKSLRKFVDGKGRSKCC | ||||||
Glycosylation | 82 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 118 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 168 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the CTL (choline transporter-like) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length628
- Mass (Da)71,809
- Last updated2005-05-24 v1
- ChecksumB095D3138E9305A6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000129 EMBL· GenBank· DDBJ | EAL62922.1 EMBL· GenBank· DDBJ | Genomic DNA |