Q54H71 · ADPRH_DICDI
- ProteinADP-ribosylhydrolase ARH1
- Geneadprh
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids392 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
Catalytic activity
- N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O = ADP-D-ribose + L-arginyl-[protein]
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 79 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 80 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 81 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 109 | substrate | ||||
Sequence: K | ||||||
Binding site | 159 | substrate | ||||
Sequence: G | ||||||
Binding site | 348 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 350 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 350 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 351 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ADP-ribosylarginine hydrolase activity | |
Molecular Function | metal ion binding | |
Biological Process | protein modification process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADP-ribosylhydrolase ARH1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54H71
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000328209 | 1-392 | ADP-ribosylhydrolase ARH1 | |||
Sequence: MFHKFISTLTNKKITQTIMGTINKENIKPAMLLSAFGDACGYKNGIWEFEKSPSRIYEHYEYLGGYKNLKINKKDWRLSDDTIMHIATAIAITRPTNTDNESICKELAKAYIHSMEDMAGRAPGIQTINSVSLMTQTGMRSKVYQWNEIDFSDRAGGCGGSMRSMCIGFKYWSDEQLDTLIELSIESGRITHNNPVGFLGALVSALFASYAIRSIPPKTWPLKLMTEVMPKAREYLEKTSNSSNRNIENYEKGWNYFWNSWKSYLKLRQIPSNPDELKAANDKGIDYPVFPKDYSDYKVRENFYHSISFSGWGGSSGHDSCIIAYDALLGSADNWEEMIKRSVLHGGDNDSTGAIGCCWWGALYGFNGVPECNYEKIEYKSIIEGLAKEISN |
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 125-127 | Substrate | ||||
Sequence: IQT | ||||||
Region | 192-194 | Substrate | ||||
Sequence: HNN | ||||||
Region | 309-311 | Substrate | ||||
Sequence: FSG | ||||||
Region | 315-316 | Substrate | ||||
Sequence: SS |
Sequence similarities
Belongs to the ADP-ribosylglycohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length392
- Mass (Da)44,362
- Last updated2005-05-24 v1
- ChecksumB99C7063F05AB67C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAFI02000148 EMBL· GenBank· DDBJ | EAL62549.1 EMBL· GenBank· DDBJ | Genomic DNA |