Q54F44 · NOXC_DICDI
- ProteinSuperoxide-generating NADPH oxidase heavy chain subunit C
- GenenoxC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1142 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Critical component of the membrane-bound oxidase that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior (By similarity).
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 519 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 521 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 523 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 525 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 530 | Ca2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 665 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 679 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 755 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 768 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 849-855 | FAD (UniProtKB | ChEBI) | ||||
Sequence: HPFTMTS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | NADPH oxidase complex | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | heme binding | |
Molecular Function | superoxide-generating NAD(P)H oxidase activity | |
Biological Process | defense response | |
Biological Process | defense response to bacterium | |
Biological Process | sorocarp development | |
Biological Process | sporulation resulting in formation of a cellular spore | |
Biological Process | superoxide anion generation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSuperoxide-generating NADPH oxidase heavy chain subunit C
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ54F44
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 583-603 | Helical | ||||
Sequence: FFISLFFIINSILVITSFLNV | ||||||
Transmembrane | 627-647 | Helical | ||||
Sequence: LIEFNAAIILMTMCKQLFTMI | ||||||
Transmembrane | 667-687 | Helical | ||||
Sequence: LIGYTLIIASFLHTIGWIVGM | ||||||
Transmembrane | 720-740 | Helical | ||||
Sequence: LPGVTGFIMISFLIIMAILSL | ||||||
Transmembrane | 754-774 | Helical | ||||
Sequence: SHHLFIGFYVLLILHGTMGWI |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Prevents formation of fruiting bodies.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000361529 | 1-1142 | Superoxide-generating NADPH oxidase heavy chain subunit C | |||
Sequence: MEKQKNISIKKFANPLSFPHEFRTNLHKSTFLDASLLELPNISVDKTKNENNFSITDKILMESLKENEFKIREFIKNQESGNRVLMIDKNSLKELFNINDNQALDLIFNQYVQSTRPNLIRKSSNSSLNIDLKKEIKKKTKKSRKSFSRNSKLNNNDSKIDDKNDNYIDKINDINNFNSDIEEIFKKKKEIENTLKIPIGGNSFPIPVEFNNNNNNNNNNNNNNNNNYNNNIDNNNNNNNNNNNNNINNCNNNNINNDNNNNNNNDNDNNNINTVDNHDDDIINNSNNFNKNEYPSSNISPISPKSSISSFPTNLNNSINNTGSMVSDSLSSCRNSISSSSIDSSVASIPITIQSIDFEDKNIKSDQFKIISKSNIENTIETNPIPPFNQTNNQCEVQLQSHSLPTILKQPHIYKSKSFSSSINSNSKIKKIKKSRSFEIESKINLFDVINHIYLNLSKVGSEEQKITSVFKLYDIYDKGFISRDDLKEVLNYRTKQNGLKFQDFTMESLIDHIFQQFDKNMDGYIDFEEFKSELTINNENKVKEKEENTNYNFKEENIGIYTEKESFHSLKRYLKIEGSKLFFISLFFIINSILVITSFLNVHANNKRAIELFGPGVYITRIAAQLIEFNAAIILMTMCKQLFTMIRNTKFKFLFPVDKYMTFHKLIGYTLIIASFLHTIGWIVGMAVATGKPDNIFYDCLAPHFKFRPTVWEMIFNSLPGVTGFIMISFLIIMAILSLKIIRKSNFELFYYSHHLFIGFYVLLILHGTMGWIRPPTFWKWFIVPGFFYTVDRSFRLFKRTHRVEVLDYCLKNERVINLTFSKPPSFDYKPGQYLLINVPHISKLQWHPFTMTSSPLEDKIYVHIRVTGNWTKKLFRWLSIKKQLQQQQQLYNNIKQQNVLPDGSNFIINNNNNIDQIDLEIGLKPFRINIDGPFGSSSQYALKQKQVILVGAGIGVSPMASLLKDISLKKQRLQLLNQGDQIALEQSKNEITTKFGLGNLEKVHFFWLNRDQHSFQWFEDLLIDISTNGNSNLPKISINTFNTRVFPKNDVRVFMLWNGLDKLFKAQGLDPTTNLPFKTHWGRPNWDTIFQYYSKKYSGESISVFCCGPSQLSKELYEKCRYYTCLKTGGTKFYFHKENF |
Proteomic databases
Expression
Developmental stage
Expressed during development. Low expression starts at 8 hours development, and increases sharply in fruiting bodies.
Interaction
Structure
Family & Domains
Features
Showing features for region, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 135-166 | Disordered | ||||
Sequence: EIKKKTKKSRKSFSRNSKLNNNDSKIDDKNDN | ||||||
Coiled coil | 172-246 | |||||
Sequence: NDINNFNSDIEEIFKKKKEIENTLKIPIGGNSFPIPVEFNNNNNNNNNNNNNNNNNYNNNIDNNNNNNNNNNNNN | ||||||
Region | 208-298 | Disordered | ||||
Sequence: VEFNNNNNNNNNNNNNNNNNYNNNIDNNNNNNNNNNNNNINNCNNNNINNDNNNNNNNDNDNNNINTVDNHDDDIINNSNNFNKNEYPSSN | ||||||
Domain | 462-497 | EF-hand 1 | ||||
Sequence: SEEQKITSVFKLYDIYDKGFISRDDLKEVLNYRTKQ | ||||||
Domain | 506-541 | EF-hand 2 | ||||
Sequence: TMESLIDHIFQQFDKNMDGYIDFEEFKSELTINNEN | ||||||
Domain | 622-766 | Ferric oxidoreductase | ||||
Sequence: RIAAQLIEFNAAIILMTMCKQLFTMIRNTKFKFLFPVDKYMTFHKLIGYTLIIASFLHTIGWIVGMAVATGKPDNIFYDCLAPHFKFRPTVWEMIFNSLPGVTGFIMISFLIIMAILSLKIIRKSNFELFYYSHHLFIGFYVLLI | ||||||
Domain | 794-942 | FAD-binding FR-type | ||||
Sequence: RSFRLFKRTHRVEVLDYCLKNERVINLTFSKPPSFDYKPGQYLLINVPHISKLQWHPFTMTSSPLEDKIYVHIRVTGNWTKKLFRWLSIKKQLQQQQQLYNNIKQQNVLPDGSNFIINNNNNIDQIDLEIGLKPFRINIDGPFGSSSQY |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,142
- Mass (Da)132,499
- Last updated2005-05-24 v1
- ChecksumEE780670085977A9
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 224-225 | in Ref. 1; AAO72635 | ||||
Sequence: NN → II |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY224390 EMBL· GenBank· DDBJ | AAO72635.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAFI02000175 EMBL· GenBank· DDBJ | EAL61883.1 EMBL· GenBank· DDBJ | Genomic DNA |