Q54F44 · NOXC_DICDI

Function

function

Critical component of the membrane-bound oxidase that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior (By similarity).

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

111421002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site519Ca2+ (UniProtKB | ChEBI)
Binding site521Ca2+ (UniProtKB | ChEBI)
Binding site523Ca2+ (UniProtKB | ChEBI)
Binding site525Ca2+ (UniProtKB | ChEBI)
Binding site530Ca2+ (UniProtKB | ChEBI)
Binding site665Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site679Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site755Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site768Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site849-855FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentNADPH oxidase complex
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionheme binding
Molecular Functionsuperoxide-generating NAD(P)H oxidase activity
Biological Processdefense response
Biological Processdefense response to bacterium
Biological Processsorocarp development
Biological Processsporulation resulting in formation of a cellular spore
Biological Processsuperoxide anion generation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Superoxide-generating NADPH oxidase heavy chain subunit C
  • EC number
  • Alternative names
    • NADPH oxidase C
    • Superoxide-generating NADPH oxidase flavocytochrome C

Gene names

    • Name
      noxC
    • ORF names
      DDB_G0291117

Organism names

Accessions

  • Primary accession
    Q54F44
  • Secondary accessions
    • Q86MX0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane583-603Helical
Transmembrane627-647Helical
Transmembrane667-687Helical
Transmembrane720-740Helical
Transmembrane754-774Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Prevents formation of fruiting bodies.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003615291-1142Superoxide-generating NADPH oxidase heavy chain subunit C

Proteomic databases

Expression

Developmental stage

Expressed during development. Low expression starts at 8 hours development, and increases sharply in fruiting bodies.

Interaction

Subunit

Composed of a heavy chain and a light chain.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, domain.

TypeIDPosition(s)Description
Region135-166Disordered
Coiled coil172-246
Region208-298Disordered
Domain462-497EF-hand 1
Domain506-541EF-hand 2
Domain622-766Ferric oxidoreductase
Domain794-942FAD-binding FR-type

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,142
  • Mass (Da)
    132,499
  • Last updated
    2005-05-24 v1
  • Checksum
    EE780670085977A9
MEKQKNISIKKFANPLSFPHEFRTNLHKSTFLDASLLELPNISVDKTKNENNFSITDKILMESLKENEFKIREFIKNQESGNRVLMIDKNSLKELFNINDNQALDLIFNQYVQSTRPNLIRKSSNSSLNIDLKKEIKKKTKKSRKSFSRNSKLNNNDSKIDDKNDNYIDKINDINNFNSDIEEIFKKKKEIENTLKIPIGGNSFPIPVEFNNNNNNNNNNNNNNNNNYNNNIDNNNNNNNNNNNNNINNCNNNNINNDNNNNNNNDNDNNNINTVDNHDDDIINNSNNFNKNEYPSSNISPISPKSSISSFPTNLNNSINNTGSMVSDSLSSCRNSISSSSIDSSVASIPITIQSIDFEDKNIKSDQFKIISKSNIENTIETNPIPPFNQTNNQCEVQLQSHSLPTILKQPHIYKSKSFSSSINSNSKIKKIKKSRSFEIESKINLFDVINHIYLNLSKVGSEEQKITSVFKLYDIYDKGFISRDDLKEVLNYRTKQNGLKFQDFTMESLIDHIFQQFDKNMDGYIDFEEFKSELTINNENKVKEKEENTNYNFKEENIGIYTEKESFHSLKRYLKIEGSKLFFISLFFIINSILVITSFLNVHANNKRAIELFGPGVYITRIAAQLIEFNAAIILMTMCKQLFTMIRNTKFKFLFPVDKYMTFHKLIGYTLIIASFLHTIGWIVGMAVATGKPDNIFYDCLAPHFKFRPTVWEMIFNSLPGVTGFIMISFLIIMAILSLKIIRKSNFELFYYSHHLFIGFYVLLILHGTMGWIRPPTFWKWFIVPGFFYTVDRSFRLFKRTHRVEVLDYCLKNERVINLTFSKPPSFDYKPGQYLLINVPHISKLQWHPFTMTSSPLEDKIYVHIRVTGNWTKKLFRWLSIKKQLQQQQQLYNNIKQQNVLPDGSNFIINNNNNIDQIDLEIGLKPFRINIDGPFGSSSQYALKQKQVILVGAGIGVSPMASLLKDISLKKQRLQLLNQGDQIALEQSKNEITTKFGLGNLEKVHFFWLNRDQHSFQWFEDLLIDISTNGNSNLPKISINTFNTRVFPKNDVRVFMLWNGLDKLFKAQGLDPTTNLPFKTHWGRPNWDTIFQYYSKKYSGESISVFCCGPSQLSKELYEKCRYYTCLKTGGTKFYFHKENF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict224-225in Ref. 1; AAO72635

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY224390
EMBL· GenBank· DDBJ
AAO72635.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000175
EMBL· GenBank· DDBJ
EAL61883.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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