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Q54DY1 · ARGJ_DICDI

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site137Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site138Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site173substrate
Binding site199substrate
Site209-210Cleavage; by autolysis
Active site210Nucleophile
Binding site210substrate
Binding site297substrate
Binding site437substrate
Binding site442substrate

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Short names
    GAT
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGS
      )

Gene names

    • Name
      argJ
    • Synonyms
      arg7
    • ORF names
      DDB_G0291916

Organism names

Accessions

  • Primary accession
    Q54DY1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-23Mitochondrion
ChainPRO_000032774324-209Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_0000327744210-442Arginine biosynthesis bifunctional protein ArgJ beta chain

Post-translational modification

The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.

Keywords

Proteomic databases

Interaction

Subunit

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    442
  • Mass (Da)
    47,724
  • Last updated
    2005-05-24 v1
  • MD5 Checksum
    15120924DD5B023B0FAB8DAB2CCEAF48
MFSNIVNKKLFQNSTTTSFLRHYSTIKNTTTSPKGFKTGTYACGLKKSGALDICLIHSEKECNVAAVFTENKVKAAPVLLSKSLIEKHKNTGFQSLIINSGGANACTGPEGEKNAQTMSFLSSKLVNAKQQSLVMSTGIIGQQLDMKKVELGITKASENLKDDWLSAAKAIMTTDKVPKLVQKQIEIQGKQVNITGICKGAGMIHPNMATMLCTLCTDADISEEALKSALKHSIDYSFNSINVDGDMSTNDTVAVFSNGLAGNKRIDSTNSKEYLLLEKAMRECATELAQMIVRDAEGATKFISVVVRGAKTEKDGKIIANSIATSSLVKTAMYGEDANWGRVLAAVGYSGADGVVPSNISMWFASGYGDNIGIGQKNDPLIAMQFLKDGQPTPKDDEKAAKLLSNKDISIIVDLNNGNQNYTMWTCDLTVDYVKANSHYRT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000186
EMBL· GenBank· DDBJ
EAL61488.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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