Q54C70 · ODPA_DICDI

Function

function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

Catalytic activity

Cofactor

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site83pyruvate (UniProtKB | ChEBI)
Binding site109pyruvate (UniProtKB | ChEBI)
Binding site109thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site110pyruvate (UniProtKB | ChEBI)
Binding site110thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site156pyruvate (UniProtKB | ChEBI)
Binding site156thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site158pyruvate (UniProtKB | ChEBI)
Binding site158thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site187Mg2+ (UniProtKB | ChEBI)
Binding site187pyruvate (UniProtKB | ChEBI)
Binding site187thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site188pyruvate (UniProtKB | ChEBI)
Binding site188thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site189pyruvate (UniProtKB | ChEBI)
Binding site189thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site216Mg2+ (UniProtKB | ChEBI)
Binding site216pyruvate (UniProtKB | ChEBI)
Binding site216thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit
Binding site218Mg2+ (UniProtKB | ChEBI)
Binding site218pyruvate (UniProtKB | ChEBI)
Binding site283thiamine diphosphate (UniProtKB | ChEBI); ligand shared with beta subunit

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Cellular Componentphagocytic vesicle
Cellular Componentpyruvate dehydrogenase complex
Molecular Functionmetal ion binding
Molecular Functionpyruvate dehydrogenase (acetyl-transferring) activity
Biological Processacetyl-CoA biosynthetic process from pyruvate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
  • EC number
  • Short names
    PDHE1-A

Gene names

    • Name
      pdhA
    • ORF names
      DDB_G0292994

Organism names

Accessions

  • Primary accession
    Q54C70

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain.

Type
IDPosition(s)Description
Transit peptide1-26Mitochondrion
ChainPRO_000032798327-377Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

Proteomic databases

Interaction

Subunit

Tetramer of 2 alpha and 2 beta subunits.

Protein-protein interaction databases

Structure

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    377
  • Mass (Da)
    41,988
  • Last updated
    2005-05-24 v1
  • MD5 Checksum
    102DBCCC72FBF95F35764F159AE0F2C8
MLSNFLKVNSKALGHIRTFASKSGEIKHNFKKADTYLCDGPSDSTVTNKDELISFFTEMSRFRRLETVCDGLYKKKLIRGFCHLYTGQEAVCAGLESAITKDDHIITAYRDHTYMLSRGATPEEIFAELLMKETGCSKGKGGSMHMFTKNFYGGNGIVGAQCPLGAGIAFAQKYNKTGNVCLAMYGDGAANQGQLFEAFNMASLWKLPVIFICENNKYGMGTSQKRSTAGHDFYTRGHYVAGLKVDGMDVFAVKEAGKYAAEWCRAGNGPIILEMDTYRYVGHSMSDPGITYRTREEVNHVRQTRDPIENIRQIILDNKIATEDQLAAIEETVRDEMEKASEKAIAAPLPQARELFTNVYLQEVPVRGVEFVNSFKP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAFI02000199
EMBL· GenBank· DDBJ
EAL60849.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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