Q54AA2 · Q54AA2_MOUSE

  • Protein
    Apoptosis-associated speck-like protein containing CARD
  • Gene
    Pycard
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentAIM2 inflammasome complex
Cellular ComponentGolgi membrane
Cellular ComponentIkappaB kinase complex
Cellular Componentmitochondrion
Cellular ComponentNLRP1 inflammasome complex
Cellular ComponentNLRP3 inflammasome complex
Cellular ComponentNLRP6 inflammasome complex
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular FunctionBMP receptor binding
Molecular Functioninterleukin-6 receptor binding
Molecular Functionmyosin I binding
Molecular Functionprotease binding
Molecular Functionprotein homodimerization activity
Molecular FunctionPyrin domain binding
Molecular Functiontropomyosin binding
Biological Processcellular response to interleukin-1
Biological Processcellular response to lipopolysaccharide
Biological Processdefense response to Gram-negative bacterium
Biological Processdefense response to virus
Biological Processinnate immune response
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Processmyeloid dendritic cell activation
Biological Processnegative regulation of canonical NF-kappaB signal transduction
Biological Processnegative regulation of cytokine production involved in inflammatory response
Biological Processnegative regulation of interferon-beta production
Biological ProcessNLRP3 inflammasome complex assembly
Biological Processpositive regulation of adaptive immune response
Biological Processpositive regulation of chemokine production
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of extrinsic apoptotic signaling pathway
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-10 production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of non-canonical NF-kappaB signal transduction
Biological Processpositive regulation of release of cytochrome c from mitochondria
Biological Processpositive regulation of T cell activation
Biological Processpositive regulation of tumor necrosis factor production
Biological Processprotein homooligomerization
Biological Processregulation of intrinsic apoptotic signaling pathway
Biological Processregulation of tumor necrosis factor-mediated signaling pathway
Biological Processtumor necrosis factor-mediated signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Apoptosis-associated speck-like protein containing CARD

Gene names

    • Name
      Pycard
    • Synonyms
      ASC

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q54AA2

Organism-specific databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-91Pyrin
Domain105-193CARD

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    193
  • Mass (Da)
    21,459
  • Last updated
    2005-05-24 v1
  • Checksum
    2A4EA40194870B31
MGRARDAILDALENLSGDELKKFKMKLLTVQLREGYGRIPRGALLQMDAIDLTDKLVSYYLESYGLELTMTVLRDMGLQELAEQLQTTKEESGAVAAAASVPAQSTARTGHFVDQHRQALIARVTEVDGVLDALHGSVLTEGQYQAVRAETTSQDKMRKLFSFVPSWNLTCKDSLLQALKEIHPYLVMDLEQS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB059327
EMBL· GenBank· DDBJ
BAB97214.1
EMBL· GenBank· DDBJ
Genomic DNA
AK152677
EMBL· GenBank· DDBJ
BAE31409.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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