Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
OX2R gene rs2653349 and rs2292041 polymorphisms in the Han population of Henan may be associated with Alzheimer's disease (AD) and the A allele may be a susceptible factor for AD
SNPs Leu72Met of the GHRL gene (rs696217) Ile408Val of the HCRTR1 gene (rs2271933) and Val308Ile of the HCRTR2 gene (rs2653349) were genotyped. None of the SNPs showed significant main or G x E effects in post-traumatic stress disorder patients.
The present study demonstrated that aa residues in the C-terminus serve an important role in the expression and signal transduction of OX2R. In addition the aa residues in different locations possess evidentially different roles.
After sequencing all orexin receptor exons one variation (rs2271933) in the OX1R gene and one variation (rs2653349) in the OX2R gene were found. However no significant differences were found in either genotypic or allelic frequency distributions between the two study groups
This study showed that Lack of Association between Genetic Polymorphism of ox2r gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population
The study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R and OX2R.
Heart failure patients with minor allele for rs7767652 upstream of hypocretin (orexin) receptor-2 (HCRTR2) were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35%
Rapid-onset obesity with hypothalamic dysfunction hypoventilation and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR2 gene.
Several single nucleotide polymorphisms (SNPs) in HCRTR2 were nominally associated with Antipsychotic-induced weight gain (AIWG) in patients of European ancestry treated with either clozapine or olanzapine. None of the SNPs in HCRTR1 were associated with AIWG.
the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence.
using lipid-mediated crystallization and protein engineering with a novel fusion chimaera the structure of the human OX2R bound to suvorexant at 2.5 A resolution is solved
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