Q546I7 · Q546I7_HUMAN
- ProteinHLA class I histocompatibility antigen
- GeneHLA-C
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids366 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | ER to Golgi transport vesicle membrane | |
Cellular Component | external side of plasma membrane | |
Cellular Component | extracellular space | |
Cellular Component | lumenal side of endoplasmic reticulum membrane | |
Cellular Component | phagocytic vesicle membrane | |
Cellular Component | recycling endosome membrane | |
Molecular Function | peptide antigen binding | |
Molecular Function | signaling receptor binding | |
Biological Process | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent | |
Biological Process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib | |
Biological Process | immune response | |
Biological Process | positive regulation of T cell mediated cytotoxicity |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ546I7
Subcellular Location
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 306-331 | Helical | ||||
Sequence: IPIVGIVAGLAVLAVLAVLGAVMAVV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MRVMAPRTLILLLSGALALTETWA | ||||||
Chain | PRO_5015097768 | 25-366 | ||||
Sequence: CSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYGCDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAARTAEQLRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWGPSSQPTIPIVGIVAGLAVLAVLAVLGAVMAVVMCRRKSSGGKGGSCSQAASSNSAQGSDESLIACKA |
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 209-297 | Ig-like | ||||
Sequence: PKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLR | ||||||
Region | 338-366 | Disordered | ||||
Sequence: SGGKGGSCSQAASSNSAQGSDESLIACKA | ||||||
Compositional bias | 340-359 | Polar residues | ||||
Sequence: GKGGSCSQAASSNSAQGSDE |
Sequence similarities
Belongs to the MHC class I family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length366
- Mass (Da)40,773
- Last updated2005-05-24 v1
- Checksum2A84D41389A0486A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 340-359 | Polar residues | ||||
Sequence: GKGGSCSQAASSNSAQGSDE |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FJ785724 EMBL· GenBank· DDBJ | ACN97190.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM543703 EMBL· GenBank· DDBJ | ADU18055.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU319204 EMBL· GenBank· DDBJ | ANG08620.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF156574 EMBL· GenBank· DDBJ | ASM62163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF156575 EMBL· GenBank· DDBJ | ASM62164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH173572 EMBL· GenBank· DDBJ | AWM62613.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH374090 EMBL· GenBank· DDBJ | AWM63095.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH721291 EMBL· GenBank· DDBJ | AXN55777.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH721292 EMBL· GenBank· DDBJ | AXN55778.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH721304 EMBL· GenBank· DDBJ | AXN55788.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH758975 EMBL· GenBank· DDBJ | AZL48733.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK005647 EMBL· GenBank· DDBJ | AZL48953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK005656 EMBL· GenBank· DDBJ | AZL48962.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK300317 EMBL· GenBank· DDBJ | AZU90486.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK336338 EMBL· GenBank· DDBJ | AZU90585.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257764 EMBL· GenBank· DDBJ | BBD34082.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC257765 EMBL· GenBank· DDBJ | BBD34083.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC326228 EMBL· GenBank· DDBJ | BBD74464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC326229 EMBL· GenBank· DDBJ | BBD74465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR761801 EMBL· GenBank· DDBJ | CAA9893195.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR798129 EMBL· GenBank· DDBJ | CAB4529268.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ420244 EMBL· GenBank· DDBJ | CAD12429.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ420246 EMBL· GenBank· DDBJ | CAD12431.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FR675924 EMBL· GenBank· DDBJ | CBW44112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH254924 EMBL· GenBank· DDBJ | QAV56455.1 EMBL· GenBank· DDBJ | mRNA | ||
MK814910 EMBL· GenBank· DDBJ | QDC33465.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK814925 EMBL· GenBank· DDBJ | QDC33480.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938178 EMBL· GenBank· DDBJ | QDK63332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938222 EMBL· GenBank· DDBJ | QDK63374.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938231 EMBL· GenBank· DDBJ | QDK63382.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938234 EMBL· GenBank· DDBJ | QDK63385.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938238 EMBL· GenBank· DDBJ | QDK63389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938243 EMBL· GenBank· DDBJ | QDK63394.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938250 EMBL· GenBank· DDBJ | QDK63401.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938252 EMBL· GenBank· DDBJ | QDK63403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK938271 EMBL· GenBank· DDBJ | QDK63422.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954476 EMBL· GenBank· DDBJ | QDK63456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954492 EMBL· GenBank· DDBJ | QDK63472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954570 EMBL· GenBank· DDBJ | QDK63550.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954645 EMBL· GenBank· DDBJ | QDK63623.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954650 EMBL· GenBank· DDBJ | QDK63628.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954671 EMBL· GenBank· DDBJ | QDK63648.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954683 EMBL· GenBank· DDBJ | QDK63659.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954695 EMBL· GenBank· DDBJ | QDK63670.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954720 EMBL· GenBank· DDBJ | QDK63695.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954758 EMBL· GenBank· DDBJ | QDK63732.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954776 EMBL· GenBank· DDBJ | QDK63749.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954811 EMBL· GenBank· DDBJ | QDK63784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK954834 EMBL· GenBank· DDBJ | QDK63807.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016557 EMBL· GenBank· DDBJ | QDK63832.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016565 EMBL· GenBank· DDBJ | QDK63840.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016566 EMBL· GenBank· DDBJ | QDK63841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016569 EMBL· GenBank· DDBJ | QDK63844.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016573 EMBL· GenBank· DDBJ | QDK63848.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016610 EMBL· GenBank· DDBJ | QDK63885.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016686 EMBL· GenBank· DDBJ | QDK63960.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016701 EMBL· GenBank· DDBJ | QDK63975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016718 EMBL· GenBank· DDBJ | QDK63992.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016737 EMBL· GenBank· DDBJ | QDK64010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016756 EMBL· GenBank· DDBJ | QDK64029.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016762 EMBL· GenBank· DDBJ | QDK64035.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016764 EMBL· GenBank· DDBJ | QDK64037.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016787 EMBL· GenBank· DDBJ | QDK64060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016820 EMBL· GenBank· DDBJ | QDK64093.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN016830 EMBL· GenBank· DDBJ | QDK64103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN136834 EMBL· GenBank· DDBJ | QDK64282.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN187920 EMBL· GenBank· DDBJ | QFG58531.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN623595 EMBL· GenBank· DDBJ | QFZ94709.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN787331 EMBL· GenBank· DDBJ | QGY63759.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN787357 EMBL· GenBank· DDBJ | QGY63784.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN787394 EMBL· GenBank· DDBJ | QGY63819.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN032105 EMBL· GenBank· DDBJ | QGY93910.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT015573 EMBL· GenBank· DDBJ | QIA49076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN993652 EMBL· GenBank· DDBJ | QIJ58244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT303872 EMBL· GenBank· DDBJ | QJS41617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT415933 EMBL· GenBank· DDBJ | QJS41632.1 EMBL· GenBank· DDBJ | Genomic DNA |