Q545C3 · Q545C3_MOUSE
- ProteinCyclin-dependent kinase 4
- GeneCdk4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids303 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Publications for Q545C3
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
- CategoriesFunction, PTM / Processing
- SourceMGI: 88357
Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: a Kit-KL interaction critical for meiosis.
- CategoriesFunction, Expression
- SourceMGI: 88357
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
- CategoriesFunction, Expression
- SourceMGI: 88357
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
- CategoriesSequences, Expression
- SourceMGI: 88357
- PubMed
- Europe PMC
- Cell Growth Differ 8:1139-1150 ()
Mapped toDifferential expression of D-type G1 cyclins during mouse development and liver regeneration in vivo.
- CategoryExpression
- SourceMGI: 88357
Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients.
- CategorySequences
- SourceMGI: 88357
- PubMed
- Europe PMC
- Cancer Res 57:169-175 ()
Mapped toRegulation of the catalytic subunit (p34PSK-J3/cdk4) for the major D-type cyclin in mature B lymphocytes.
- CategoryFunction
- SourceMGI: 88357
- PubMed
- Europe PMC
- J Immunol 156:539-548 ()
Mapped toGermline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.
- CategoryFunction
- SourceMGI: 88357
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.
- CategoriesSequences, Interaction
- SourceMGI: 88357
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
- CategoryInteraction
- SourceMGI: 88357
Cloning and characterization of murine p16INK4a and p15INK4b genes.
- CategorySequences
- SourceMGI: 88357
- PubMed
- Europe PMC
- Oncogene 11:635-645 ()
Growth suppression by p16ink4 requires functional retinoblastoma protein.
- CategoryFunction
- SourceMGI: 88357
Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity.
- AnnotationCyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity.
- SourceGeneRif: 12567
Cyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
- AnnotationCyclin D-CDK4 Disulfide Bond Attenuates Pulmonary Vascular Cell Proliferation.
- CategoryFunction
- SourceGeneRif: 12567
Cyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
- AnnotationCyclin D1-Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors.
- CategoryFunction
- SourceGeneRif: 12567
CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
- AnnotationCDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue.
- CategoryPTM / Processing
- SourceGeneRif: 12567
Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
- AnnotationInhibition of CDK4/6 regulates AD pathology neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
- CategoryFunction
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
- CategoryFunction
- SourceMGI: 88357