The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently upregulated in mice after traumatic brain injury and CCL2 modulates the complement system in microglia.
mice with lung epithelial cell-specific deletion of CCL12 were protected from bleomycin-induced fibrosis and had expression of CCL2 and CCL7 similar to that of control mice treated with bleomycin.
results provide evidence for a previously unrecognized role of IKKbeta in the regulation of the growth plate that is mediated through stimulation-independent downregulation of MCP-5 in the perichondrium.
tumours are characterized by expression of inflammatory chemokines (CCL2 CCL5 CCL7 CCL8 CCL12 CXCL9 CXCL10 and CX3CL1) reflected by an enrichment of activated Foxp3(-) and Foxp3(+) T cells
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