Q544Z2 · Q544Z2_MOUSE
- ProteinRhombotin-2
- GeneLmo2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids158 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q544Z2
Jak2 is essential for signaling through a variety of cytokine receptors.
- CategoryFunction
- SourceMGI: 102811
Cited inMapped toThe T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.
- CategoryFunction
- SourceMGI: 102811
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development.
- CategoryFunction
- SourceMGI: 102811
Mapped toT cell tumours of disparate phenotype in mice transgenic for Rbtn-2.
- CategoryFunction
- SourceMGI: 102811
- PubMed
- Europe PMC
- Oncogene 9:3675-3681 ()
Mapped toAbsence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.
- CategoryFunction
- SourceMGI: 102811
Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition.
- AnnotationOverexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition.
- CategoryFunction
The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
- AnnotationThe transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis.
- CategoryFunction
Endothelial Cyp26b1 restrains murine heart valve growth during development.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 102811
LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.
- AnnotationLMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice.
- CategoryFunction
The NUP98-HOXD13 fusion oncogene induces thymocyte self-renewal via Lmo2/Lyl1.
- AnnotationNHD13 transgenic mice lacking Lyl1 showed accelerated T-ALL and absence of transformation to AML associated with a loss of multipotent progenitors in the bone marrow. Thus multiple T cell oncogenes induce thymocyte self-renewal via Lmo2/Lyl1.
- CategoriesFunction, Expression
Lmo2 expression defines tumor cell identity during T-cell leukemogenesis.
- AnnotationTransient LMO2 expression is sufficient for oncogenic function and induction of T-ALL. The resulting T-ALLs lacked LMO2 and its target-gene expression and histologically transcriptionally and genetically similar to human LMO2-driven T-ALL.
- CategoriesFunction, Expression
Epigenetic dysregulation of ZEB1 is involved in LMO2-promoted T-cell acute lymphoblastic leukaemia leukaemogenesis.
- CategoriesFunction, Interaction
- SourceMGI: 102811
BRACHYURY directs histone acetylation to target loci during mesoderm development.
- CategoryFunction
- SourceMGI: 102811
LMO2 is required for TAL1 DNA binding activity and initiation of definitive haematopoiesis at the haemangioblast stage.
- AnnotationGenome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1/LMO2/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
- CategoryFunction
Essential roles for Cdx in murine primitive hematopoiesis.
- CategoryFunction
- SourceMGI: 102811
LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia.
- CategoriesFunction, Sequences
- SourceMGI: 102811
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
- AnnotationDNM2 mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 signalling.
- CategoriesFunction, Phenotypes & Variants
The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression.
- CategoriesFunction, Interaction
- SourceMGI: 102811
Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
- AnnotationHhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
- CategoryFunction
LMO2 induces T-cell leukemia with epigenetic deregulation of CD4.
- CategoryFunction
- SourceMGI: 102811
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
- AnnotationHHEX is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
- CategoryFunction
Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALL.
- AnnotationLyl1 is critical for all oncogenic functions of Lmo2 including upregulation of a stem cell-like gene signature aberrant self-renewal of thymocytes and subsequent generation of T-cell leukemia.
- CategoryFunction