Q544Y8 · Q544Y8_MOUSE
- ProteinGranulin
- GeneGrn
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids589 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q544Y8
An MMTV integration site maps near the distal end of mouse chromosome 11.
- CategoriesFunction, Sequences
- SourceMGI: 95832
Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).
- CategorySequences
- SourceMGI: 95832
Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury.
- AnnotationSelective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury.
- SourceGeneRif: 14824
Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
- AnnotationPeripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
- CategoryFunction
- SourceGeneRif: 14824
Progranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model.
- AnnotationProgranulin deficiency attenuates tubulointerstitial injury in a mouse unilateral ureteral obstruction model.
- CategoryFunction
Progranulin promotes regulatory T cells plasticity by mitochondrial metabolism through AMPK/PGC-1alpha pathway in ARDS.
- AnnotationProgranulin promotes regulatory T cells plasticity by mitochondrial metabolism through AMPK/PGC-1alpha pathway in ARDS.
- CategoryNames
- SourceGeneRif: 14824
Targeting progranulin alleviated silica particles-induced pulmonary inflammation and fibrosis via decreasing Il-6 and Tgf-beta1/Smad.
- AnnotationTargeting progranulin alleviated silica particles-induced pulmonary inflammation and fibrosis via decreasing Il-6 and Tgf-beta1/Smad.
- CategoryFunction
- SourceGeneRif: 14824
Increased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia.
- AnnotationIncreased circulating progranulin is not sufficient to induce cardiac dysfunction or supraventricular arrhythmia.
- CategoryFamily & Domains
- SourceGeneRif: 14824
Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions.
- AnnotationProgranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions.
- CategorySequences
Regulation of extracellular progranulin in medial prefrontal cortex.
- AnnotationRegulation of extracellular progranulin in medial prefrontal cortex.
- CategoryExpression
Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction.
- CategorySequences
- SourceMGI: 95832
Progranulin inhibits fibrosis by interacting with and up-regulating DNAJC3 during mouse skin wound healing.
- AnnotationProgranulin inhibits fibrosis by interacting with and up-regulating DNAJC3 during mouse skin wound healing.
- CategoryFunction
- SourceGeneRif: 14824
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
- AnnotationProgranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
- CategoryPhenotypes & Variants
- SourceGeneRif: 14824
Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
- AnnotationPatients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
- CategoryFunction
- SourceGeneRif: 14824
FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 95832