Comparing protein profiles between KIBRA knockout and wild-type mouse brain showed significantly decreased Rab27a. Rab27a is stabilized by interacting with KIBRA which prevents ubiquitination and degradation via the ubiquitin-proteasome pathway.
In conclusion we demonstrated that when Rab27a is knocked down in melanocytes Rab27a and Mlph protein levels are decreased but mRNA levels of Mlph are not changed and Mlph is decreased due to promoting proteasomal degradation in the absence of Rab27a.
a3 directly interacted with the GDP-bound forms of Rab7 and Rab27A. These findings reveal a novel role for the proton pump V-ATPase in secretory lysosome trafficking and an unexpected mechanistic link with Rab GTPases.
IRF-1 regulates Rab27a transcription and extracellular vesicles secretion leading to oxidized phospholipids activation of neutrophils and subsequent hepatic ischemia reperfusion injury
this study shows that Rab27a and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
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