Q544E9 · Q544E9_MOUSE

  • Protein
    Tumor necrosis factor ligand superfamily member 6
  • Gene
    Fasl
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
Cytoplasmic form induces gene transcription inhibition.
Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways. Can induce apoptosis but does not appear to be essential for this process.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcaveola
Cellular Componentcytoplasmic vesicle lumen
Cellular Componentextracellular exosome
Cellular Componentlysosomal lumen
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Molecular Functioncytokine activity
Molecular Functiondeath receptor binding
Molecular Functiontumor necrosis factor receptor binding
Biological Processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Biological Processcellular response to type II interferon
Biological Processendosomal lumen acidification
Biological Processextrinsic apoptotic signaling pathway via death domain receptors
Biological Processinflammatory cell apoptotic process
Biological Processintracellular chloride ion homeostasis
Biological Processnecroptotic signaling pathway
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of endothelial cell apoptotic process
Biological Processpositive regulation of epidermal growth factor receptor signaling pathway
Biological Processpositive regulation of neuron apoptotic process
Biological Processpositive regulation of phosphatidylserine exposure on apoptotic cell surface
Biological Processrelease of sequestered calcium ion into cytosol by endoplasmic reticulum
Biological Processresponse to growth factor
Biological Processresponse to lipopolysaccharide
Biological ProcessT cell apoptotic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tumor necrosis factor ligand superfamily member 6
  • Alternative names
    • CD95 ligand
    • Fas antigen ligand

Gene names

    • Name
      Fasl
    • Synonyms
      Tnlg1a

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q544E9

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Cytoplasmic vesicle lumen
Lysosome lumen
Nucleus
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane79-103Helical

Keywords

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias30-68Pro residues
Region30-70Disordered
Region126-150Disordered
Domain144-279THD

Sequence similarities

Belongs to the tumor necrosis factor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    279
  • Mass (Da)
    31,442
  • Last updated
    2005-05-24 v1
  • Checksum
    37972E2728E0A1CA
MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias30-68Pro residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK040139
EMBL· GenBank· DDBJ
BAC30520.1
EMBL· GenBank· DDBJ
mRNA
AK141268
EMBL· GenBank· DDBJ
BAE24625.1
EMBL· GenBank· DDBJ
mRNA
LN874390
EMBL· GenBank· DDBJ
CTQ86155.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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